A child with acute myeloid leukemia presented with multiple liver lesions mimicking hepatosplenic candidiasis during the neutropenic phase following the induction chemotherapy. All the available diagnostic tools showed repeatedly negative results, including galactomannan. An enzyme-linked immunospot (ELISPOT) assay showed a high number of Aspergillus-specific T cells producing interleukin-10 [TH2(IL-10)] and a low number of Aspergillus-specific T cells producing gamma interferon [TH1(IFN-γ)], revealing invasive aspergillosis (IA) before the confirmatory biopsy. A progressive skewing from the predominance of TH2(IL-10) to a predominance of TH1(IFN-γ) was observed close to the complete resolution of the infection and foreshadowed the outcome. The ELISPOT assay holds promise for diagnosing pediatric IA.

Assessment of aspergillus-specific T cells for diagnosis of invasive aspergillosis in a leukemic child with liver lesions mimicking hepatosplenic candidiasis / Potenza, Leonardo; Barozzi, Patrizia; Rossi, Giulio; Palazzi, G; Vallerini, Daniela; Riva, Giovanni; Cellini, M; Morselli, M; Volzone, Francesco; Venturelli, C; Quadrelli, Chiara; Di Pancrazio, L; Cano, Mc; Paolucci, Paolo; Torelli, Giuseppe; Luppi, Mario. - In: CLINICAL AND VACCINE IMMUNOLOGY. - ISSN 1556-6811. - STAMPA. - 15:10(2008), pp. 1625-1628. [10.1128/CVI.00198-08]

Assessment of aspergillus-specific T cells for diagnosis of invasive aspergillosis in a leukemic child with liver lesions mimicking hepatosplenic candidiasis

POTENZA, Leonardo;BAROZZI, Patrizia;ROSSI, Giulio;VALLERINI, Daniela;RIVA, Giovanni;VOLZONE, Francesco;QUADRELLI, Chiara;PAOLUCCI, Paolo;TORELLI, Giuseppe;LUPPI, Mario
2008

Abstract

A child with acute myeloid leukemia presented with multiple liver lesions mimicking hepatosplenic candidiasis during the neutropenic phase following the induction chemotherapy. All the available diagnostic tools showed repeatedly negative results, including galactomannan. An enzyme-linked immunospot (ELISPOT) assay showed a high number of Aspergillus-specific T cells producing interleukin-10 [TH2(IL-10)] and a low number of Aspergillus-specific T cells producing gamma interferon [TH1(IFN-γ)], revealing invasive aspergillosis (IA) before the confirmatory biopsy. A progressive skewing from the predominance of TH2(IL-10) to a predominance of TH1(IFN-γ) was observed close to the complete resolution of the infection and foreshadowed the outcome. The ELISPOT assay holds promise for diagnosing pediatric IA.
2008
15
10
1625
1628
Assessment of aspergillus-specific T cells for diagnosis of invasive aspergillosis in a leukemic child with liver lesions mimicking hepatosplenic candidiasis / Potenza, Leonardo; Barozzi, Patrizia; Rossi, Giulio; Palazzi, G; Vallerini, Daniela; Riva, Giovanni; Cellini, M; Morselli, M; Volzone, Francesco; Venturelli, C; Quadrelli, Chiara; Di Pancrazio, L; Cano, Mc; Paolucci, Paolo; Torelli, Giuseppe; Luppi, Mario. - In: CLINICAL AND VACCINE IMMUNOLOGY. - ISSN 1556-6811. - STAMPA. - 15:10(2008), pp. 1625-1628. [10.1128/CVI.00198-08]
Potenza, Leonardo; Barozzi, Patrizia; Rossi, Giulio; Palazzi, G; Vallerini, Daniela; Riva, Giovanni; Cellini, M; Morselli, M; Volzone, Francesco; Vent...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/612462
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 10
social impact