An increasing number of observations indicate that prostaglandin synthesis inhibition is not a satisfactory explanation for the antinociceptive activity of the non-steroidal anti-inflammatory drugs. In the hot-plate test performed 1 or 2 h after ketorolac at 40, 70 and 100 mg/kg i.p., the drug does not display any significant antinociceptive activity. Nor, at the two higher doses used, does it affect the cortical and pontine serotonin binding capacity of rat brain membranes 2 h after treatment. The data suggest that this lack of antinociceptive activity in the hot-plate test is associated with the drug's inability to affect the central serotoninergic system.
Lack of activity of Ketorolac in hot-plate test and serotonin binding capacity of brain membranes in rats / Vitale, Giovanni; Sandrini, Maurizio; Pini, Luigi Alberto. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - STAMPA. - 41(3-4):(1994), pp. 184-187.
Lack of activity of Ketorolac in hot-plate test and serotonin binding capacity of brain membranes in rats
VITALE, Giovanni;SANDRINI, Maurizio;PINI, Luigi Alberto
1994
Abstract
An increasing number of observations indicate that prostaglandin synthesis inhibition is not a satisfactory explanation for the antinociceptive activity of the non-steroidal anti-inflammatory drugs. In the hot-plate test performed 1 or 2 h after ketorolac at 40, 70 and 100 mg/kg i.p., the drug does not display any significant antinociceptive activity. Nor, at the two higher doses used, does it affect the cortical and pontine serotonin binding capacity of rat brain membranes 2 h after treatment. The data suggest that this lack of antinociceptive activity in the hot-plate test is associated with the drug's inability to affect the central serotoninergic system.Pubblicazioni consigliate
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