This study was aimed at investigating the effects of iron overload on the onset and outcome of cerebral cryptococcosis. To this purpose, iron dextran-administered mice were intracerebrally challenged with virulent melanogenic and avirulent non-melanogenic strains of Cryptococcus neoformans. The results shown here provide the first evidence that iron overload exacerbates the outcome of cryptococcal meningoencephalitis, irrespective of the fungal strain employed; pathogen colonization of the brain is facilitated, local cytokine response is delayed and/or prevented.
Iron overload exacerbates experimental meningoencephalitis by Cryptococcus neoformans / R., Barluzzi; S., Saleppico; A., Nocentini; J. R., Boelaert; Neglia, Rachele Giovanna; F., Bistoni; Blasi, Elisabetta. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 132:1-2(2002), pp. 140-146. [10.1016/S0165-5728(02)00324-7]
Iron overload exacerbates experimental meningoencephalitis by Cryptococcus neoformans
NEGLIA, Rachele Giovanna;BLASI, Elisabetta
2002
Abstract
This study was aimed at investigating the effects of iron overload on the onset and outcome of cerebral cryptococcosis. To this purpose, iron dextran-administered mice were intracerebrally challenged with virulent melanogenic and avirulent non-melanogenic strains of Cryptococcus neoformans. The results shown here provide the first evidence that iron overload exacerbates the outcome of cryptococcal meningoencephalitis, irrespective of the fungal strain employed; pathogen colonization of the brain is facilitated, local cytokine response is delayed and/or prevented.Pubblicazioni consigliate
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