Ph-positive chronic myeloid leukemia (CML) mimicking essential thrombocythemia (ET) at onset seems to be a distinct clinical entity. Whether this rare clinical form of CML is associated with single, specific variants of BCR/ABL transcripts is a matter of debate. Among 82 consecutive patients with Ph-positive CML, we identified 3 patients in which the disease mimicked ET at presentation, because-of marked thrombocytosis and moderate leukocytosis, with few immature myeloid cells in peripheral blood and blood basophilia in 2 of them. Molecular analysis with the reverse transcriptase-polymerase chain reaction technique showed the presence of b2a2, b3a2, and b3a2-b2a2 transcript variants in the three patients, respectively. The results of our study together with a review of literature data suggest that different BCR/ABL transcript variants may occur in CML mimicking ET, without an apparently significant prevalence of one type.

Chronic myeloid leukemia with thrombocythemic onset may be associated with different BCR/ABL variant transcripts / Emilia, Giovanni; Luppi, Mario; Ferrari, Mg; Temperani, Paola; Marasca, Roberto; Giacobbi, F; Vaccari, Paola; Bandieri, E; Di Donato, C; Carapezzi, C; Torelli, Giuseppe. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 101:(1998), pp. 75-77.

Chronic myeloid leukemia with thrombocythemic onset may be associated with different BCR/ABL variant transcripts

EMILIA, Giovanni;LUPPI, Mario;TEMPERANI, Paola;MARASCA, Roberto;VACCARI, Paola;TORELLI, Giuseppe
1998

Abstract

Ph-positive chronic myeloid leukemia (CML) mimicking essential thrombocythemia (ET) at onset seems to be a distinct clinical entity. Whether this rare clinical form of CML is associated with single, specific variants of BCR/ABL transcripts is a matter of debate. Among 82 consecutive patients with Ph-positive CML, we identified 3 patients in which the disease mimicked ET at presentation, because-of marked thrombocytosis and moderate leukocytosis, with few immature myeloid cells in peripheral blood and blood basophilia in 2 of them. Molecular analysis with the reverse transcriptase-polymerase chain reaction technique showed the presence of b2a2, b3a2, and b3a2-b2a2 transcript variants in the three patients, respectively. The results of our study together with a review of literature data suggest that different BCR/ABL transcript variants may occur in CML mimicking ET, without an apparently significant prevalence of one type.
1998
101
75
77
Chronic myeloid leukemia with thrombocythemic onset may be associated with different BCR/ABL variant transcripts / Emilia, Giovanni; Luppi, Mario; Ferrari, Mg; Temperani, Paola; Marasca, Roberto; Giacobbi, F; Vaccari, Paola; Bandieri, E; Di Donato, C; Carapezzi, C; Torelli, Giuseppe. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 101:(1998), pp. 75-77.
Emilia, Giovanni; Luppi, Mario; Ferrari, Mg; Temperani, Paola; Marasca, Roberto; Giacobbi, F; Vaccari, Paola; Bandieri, E; Di Donato, C; Carapezzi, C;...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/612110
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