Ph-positive chronic myeloid leukemia (CML) mimicking essential thrombocythemia (ET) at onset seems to be a distinct clinical entity. Whether this rare clinical form of CML is associated with single, specific variants of BCR/ABL transcripts is a matter of debate. Among 82 consecutive patients with Ph-positive CML, we identified 3 patients in which the disease mimicked ET at presentation, because-of marked thrombocytosis and moderate leukocytosis, with few immature myeloid cells in peripheral blood and blood basophilia in 2 of them. Molecular analysis with the reverse transcriptase-polymerase chain reaction technique showed the presence of b2a2, b3a2, and b3a2-b2a2 transcript variants in the three patients, respectively. The results of our study together with a review of literature data suggest that different BCR/ABL transcript variants may occur in CML mimicking ET, without an apparently significant prevalence of one type.

Chronic myeloid leukemia with thrombocythemic onset may be associated with different BCR/ABL variant transcripts / Emilia, Giovanni; Luppi, Mario; Ferrari, Mg; Temperani, Paola; Marasca, Roberto; Giacobbi, F; Vaccari, Paola; Bandieri, E; Di Donato, C; Carapezzi, C; Torelli, Giuseppe. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 101:(1998), pp. 75-77.

Chronic myeloid leukemia with thrombocythemic onset may be associated with different BCR/ABL variant transcripts

EMILIA, Giovanni;LUPPI, Mario;TEMPERANI, Paola;MARASCA, Roberto;VACCARI, Paola;TORELLI, Giuseppe
1998

Abstract

Ph-positive chronic myeloid leukemia (CML) mimicking essential thrombocythemia (ET) at onset seems to be a distinct clinical entity. Whether this rare clinical form of CML is associated with single, specific variants of BCR/ABL transcripts is a matter of debate. Among 82 consecutive patients with Ph-positive CML, we identified 3 patients in which the disease mimicked ET at presentation, because-of marked thrombocytosis and moderate leukocytosis, with few immature myeloid cells in peripheral blood and blood basophilia in 2 of them. Molecular analysis with the reverse transcriptase-polymerase chain reaction technique showed the presence of b2a2, b3a2, and b3a2-b2a2 transcript variants in the three patients, respectively. The results of our study together with a review of literature data suggest that different BCR/ABL transcript variants may occur in CML mimicking ET, without an apparently significant prevalence of one type.
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Chronic myeloid leukemia with thrombocythemic onset may be associated with different BCR/ABL variant transcripts / Emilia, Giovanni; Luppi, Mario; Ferrari, Mg; Temperani, Paola; Marasca, Roberto; Giacobbi, F; Vaccari, Paola; Bandieri, E; Di Donato, C; Carapezzi, C; Torelli, Giuseppe. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 101:(1998), pp. 75-77.
Emilia, Giovanni; Luppi, Mario; Ferrari, Mg; Temperani, Paola; Marasca, Roberto; Giacobbi, F; Vaccari, Paola; Bandieri, E; Di Donato, C; Carapezzi, C; Torelli, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/612110
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