Background: We describe a multistep model of cancer genetic counselling designed to promote awareness, and disease surveillance and preventive measures for hereditary and familial breast and ovarian cancer. Patients and methods: Step T0 of the model entails information giving; this is followed by pedigree analysis and risk estimation (T1), risk communication and genetic testing (T2), and genetic test result communication (T3). User consent was required to proceed from one step to the next. Surveillance and preventive measures are proposed to at-risk users. Of the 311 subjects who requested cancer genetic counselling, consent data to each counselling step were available for 295: 93 were disease-free, 187 had breast cancer, 12 had ovarian cancer and three had breast plus ovarian cancer. Results: Consent was high at T0 (98.39%), T1 (96.40%) and T2 (99.65%). Consent decreased at the crucial points of counselling: T2 (87.71%) and T3 [genetic test result communication (85.08%), and extension of counselling to and testing of relatives (65.36%)]. Conclusions: The model fosters the user's knowledge about cancer and favours identification of at-risk subjects. Furthermore, by promoting awareness about genetic testing and surveillance measures, the algorithm enables users to make a fully informed choice of action in case of predisposing or familial cancer risk.

An oncologist-based model of cancer genetic counselling for hereditary breast and ovarian cancer / Contegiacomo, A; Pensabene, M; Capuano, I; Tauchmanova, L; Federico, Massimo; Turchetti, D; Cortesi, L; Marchetti, P; Ricevuto, E; Cianci, G; Venuta, S; Barbieri, Viola; Silingardi, Vittorio. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - STAMPA. - 15:5(2004), pp. 726-732. [10.1093/annonc/mdh183]

An oncologist-based model of cancer genetic counselling for hereditary breast and ovarian cancer

FEDERICO, Massimo;BARBIERI, Viola;SILINGARDI, Vittorio
2004

Abstract

Background: We describe a multistep model of cancer genetic counselling designed to promote awareness, and disease surveillance and preventive measures for hereditary and familial breast and ovarian cancer. Patients and methods: Step T0 of the model entails information giving; this is followed by pedigree analysis and risk estimation (T1), risk communication and genetic testing (T2), and genetic test result communication (T3). User consent was required to proceed from one step to the next. Surveillance and preventive measures are proposed to at-risk users. Of the 311 subjects who requested cancer genetic counselling, consent data to each counselling step were available for 295: 93 were disease-free, 187 had breast cancer, 12 had ovarian cancer and three had breast plus ovarian cancer. Results: Consent was high at T0 (98.39%), T1 (96.40%) and T2 (99.65%). Consent decreased at the crucial points of counselling: T2 (87.71%) and T3 [genetic test result communication (85.08%), and extension of counselling to and testing of relatives (65.36%)]. Conclusions: The model fosters the user's knowledge about cancer and favours identification of at-risk subjects. Furthermore, by promoting awareness about genetic testing and surveillance measures, the algorithm enables users to make a fully informed choice of action in case of predisposing or familial cancer risk.
2004
15
5
726
732
An oncologist-based model of cancer genetic counselling for hereditary breast and ovarian cancer / Contegiacomo, A; Pensabene, M; Capuano, I; Tauchmanova, L; Federico, Massimo; Turchetti, D; Cortesi, L; Marchetti, P; Ricevuto, E; Cianci, G; Venuta, S; Barbieri, Viola; Silingardi, Vittorio. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - STAMPA. - 15:5(2004), pp. 726-732. [10.1093/annonc/mdh183]
Contegiacomo, A; Pensabene, M; Capuano, I; Tauchmanova, L; Federico, Massimo; Turchetti, D; Cortesi, L; Marchetti, P; Ricevuto, E; Cianci, G; Venuta, ...espandi
File in questo prodotto:
File Dimensione Formato  
An oncologist-based.....pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 312.26 kB
Formato Adobe PDF
312.26 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/611863
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 23
social impact