EnglishThe effect of sumatriptan in two standard algesimetric tests and in a model of cephalalgia was evaluated in rats. The pain threshold was measured by the hot-plate and the writhing tests; cephalalgia was produced by injecting bradykinin (10 μg in a volume of 10 μl) into a common carotid artery. Sumatriptan was subcutaneously (s.c.) injected at the doses of 4, 8, 24 or 42 mg/kg; morphine (5 or 10 mg/kg s.c.) and indomethacin (5 or 10 mg/kg s.c) were used as standard analgesic drugs. Sumatriptan had no analgesic activity either in the hot-plate test or in the writhing test. On the other hand, at 24 and 42 mg/kg it dose-dependently reduced the response to the intracarotid injection of bradykinin (vocalization and tachypnea), this effect being prevented by the 5-HT1B receptor antagonist, isamoltane. The 5-HT1D receptor antagonist BRL15572 prevented the effect of sumatriptan on bradykinin-induced tachypnea, but not the effect of sumatriptan on bradykinin-induced vocalization. These data demonstrate that sumatriptan is significantly effective in a reliable animal model of cephalalgia, while having no systemic analgesic activity
| Data di pubblicazione: | 2004 |
| Titolo: | Effect of sumatriptan in different models of pain in rats |
| Autore/i: | Ottani, Alessandra; Ferraris, E; Giuliani, Daniela; Mioni, C; Bertolini, Alfio; Sternieri, Emilio; Ferrari, Anna |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ejphar.2004.06.053 |
| Rivista: | |
| Volume: | 497(2) |
| Pagina iniziale: | 181 |
| Pagina finale: | 186 |
| Codice identificativo ISI: | WOS:000223451500007 |
| Codice identificativo Scopus: | 2-s2.0-4143127860 |
| Codice identificativo Pubmed: | 15306203 |
| Citazione: | Effect of sumatriptan in different models of pain in rats / Ottani, Alessandra; Ferraris, E; Giuliani, Daniela; Mioni, C; Bertolini, Alfio; Sternieri, Emilio; Ferrari, Anna. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 497(2)(2004), pp. 181-186. |
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