The aim of this study was to evaluate CXCL10 serum levels in patients with hepatitis C virus chronic infection (HCV) associated mixed cyoglobulinemia (MC), in the presence or absence of autoimmune thyroiditis (AT). CXCL10 was assayed in 50 MC patients without AT, in 40 MC patients with AT (MC+AT), in 2 gender- and age-matched control groups [50 healthy controls (without HCV or AT; control); 40 controls with AT (without HCV and MC; control+AT)]. CXCL10 was significantly higher: (1) in control+AT than in control (p<0.001); (2) in MC patients than in control (p<0.001); (3) in MC+AT patients than in control (p<0.001), control+AT (p<0.001), or in MC (p=0.002). CXCL10 was significantly increased in MC+AT patients with thyroid hypoechogenicity (388+/-147 vs 302+/-112; p=0.03), or hypothyroidism (391+/-142 vs 307+/-118; p=0.04), compared to those without. By defining a high CXCL10 level as a value at least 2 SD above the mean value of the control (>167 pg/ml), 8% of control, 22% of control+AT, 47% of MC and 80% of MC+AT had high CXCL10 (p<0.0001). In conclusion, our study is the first to demonstrate high serum levels of CXCL10 in MC and that CXCL10 in MC+AT patients are significantly higher compared to MC patients.
High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis / A., Antonelli; Ferri, Clodoveo; P., Fallahi; Ferrari, Silvia Martina; S., Frascerra; Sebastiani, Marco; F., Franzoni; F., Galetta; E., Ferrannini. - In: CYTOKINE. - ISSN 1043-4666. - STAMPA. - 42(2008), pp. 137-143.
Data di pubblicazione: | 2008 |
Titolo: | High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis. |
Autore/i: | A., Antonelli; Ferri, Clodoveo; P., Fallahi; Ferrari, Silvia Martina; S., Frascerra; Sebastiani, Marco; F., Franzoni; F., Galetta; E., Ferrannini |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 42 |
Pagina iniziale: | 137 |
Pagina finale: | 143 |
Codice identificativo ISI: | WOS:000255806400018 |
Codice identificativo Scopus: | 2-s2.0-41149122520 |
Codice identificativo Pubmed: | 18282714 |
Citazione: | High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis / A., Antonelli; Ferri, Clodoveo; P., Fallahi; Ferrari, Silvia Martina; S., Frascerra; Sebastiani, Marco; F., Franzoni; F., Galetta; E., Ferrannini. - In: CYTOKINE. - ISSN 1043-4666. - STAMPA. - 42(2008), pp. 137-143. |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
cytokine2008.pdf | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia |

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris