Study objective: To evaluate exhaled nitric oxide (eNO) during exercise in stable COPD patients.Setting: Outpatients' evaluation in a rehabilitation center.Patients: Eleven consecutive stable male COPD patients (age 65±6 years, FEV1 56±10% pred). Eight healthy (6 male; age: 51±16 years) non-smoking, non-atopic volunteers served as controls.Methods: In each subject a symptom-limited cycloergometry was carried out by monitoring eNO with the tidal-breath method to assess eNO concentration (FENO) and output ( NO ) at rest, peak exercise and recovery time.Results: Resting FENO (9.8±5.1 and 14.1±6.3 ppb respectively) and NO (4.2±2.0 and 5.9±3.4 nM*min-1 respectively) were lower though non significantly in COPD than in controls. In both groups FENO significantly decreased whereas NO significantly increased during exercise. Both parameters returned to baseline during the recovery time. Peak exercise NO but not FENO was significantly lower in COPD than in controls (7.9±5.4 and 12.7±6.0 nM*min-1 respectively, p<0.05). The rise in VNO was weakly correlated to O2 both in controls (R=0.31, p=0.002) and in COPD patients (R=0.22, p=0.03). FENO showed an inverse correlation to O2 in both groups (R= -0.53, p=0.000; R= -0.31, p=0.003 in controls and COPD respectively). Conclusions: In mild and moderate COPD patients eNO during exercise parallels that observed in normal controls. Exhaled NO output but not concentration is significantly reduced at peak exercise in COPD as compared to controls. The long-term effects of exercise training on eNo has to be evaluated by further studies.
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|Anno di pubblicazione:||2002|
|Titolo:||Exhaled nitric oxide and exercise tolerance in severe COPD patients.|
|Autori:||E. Clini; L. Bianchi; K. Foglio; M. Vitacca; N. Ambrosino|
|Appare nelle tipologie:||Articolo su rivista|
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