We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.
Human herpesvirus 6 latently infects early bone marrow progenitors in vivo / Luppi, Mario; Barozzi, Patrizia; C., Morris; Maiorana, Antonino; R., Garber; G., Bonacorsi; A., Donelli; Marasca, Roberto; A., Tabilio; Torelli, Giuseppe. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - STAMPA. - 73:1(1999), pp. 754-759.
Human herpesvirus 6 latently infects early bone marrow progenitors in vivo
LUPPI, Mario;BAROZZI, Patrizia;MAIORANA, Antonino;MARASCA, Roberto;TORELLI, Giuseppe
1999
Abstract
We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.
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