Pyrexia, leukocytosis and elevated circulating platelets associated to uterine stromal sarcoma with rhabdoid differentiation

Fever of unknown origin can be associated to soft tissues sarcoma and two cases are reported in the literature regarding sarcoma and pyrexia sustained by the tumor [1]. In the present report, we describe a case of uterine sarcoma associated to fever, leukocytosis and circulating elevated levels of platelets.A 46-year-old women with diagnosis of severe anemia (Hb 5.9 gr/dl) and uterine leiomyoma was admitted as an emergency to our hospital. The patient experienced normal cycles until 5 months before when cyclic menhorragia appeared.An office endometrial biopsy showed proliferative endometrium and the patient was submitted to progestins administration in order to reduce the cyclic bleeding. During the last 5 months, pyrexia of unknown origin appeared and the laboratory examination showed leukocytosis and increased platelets.On presentation, the physical exam was notable for an enlarged irregularly shaped uterus. There was no inguinal, axillary or supraclavicolar adenopathy.