Twenty-four sporadic colorectal adenomas were analysed for the presence of allelic loss on the short arm of chromosome 17 as well as mutations in the K-ras and p53 genes. Chromosome 17p13 allelic loss was not present in 14 out of 14 informative cases. K-ras mutations were observed in 15 out of 24 cases. A p53 gene mutation (GGC --> GAC at codon 245) was detected in two biopsies taken at a four year interval from a recurrent rectal villous adenoma. Both biopsies also contained the same K-ras gene mutation (GGT --> GTT at codon 12). The data from the recurrent rectal adenoma provide in vivo evidence that K-ras and p53 heterozygous mutations confer a proliferative advantage but together are not sufficient for malignant transformation.

Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression / DE BENEDETTI, L; Varesco, L; Pellegata, Ns; Losi, Lorena; Gismondi, V; Casarino, L; Sciallero, S; Bonelli, L; Biticchi, R; Bafico, A; Masetti, E; James, R; Heouaine, A; Ranzani, Gn; Aste, H; Ferrara, G.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 13:(1993), pp. 667-670.

Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression.

LOSI, Lorena;
1993

Abstract

Twenty-four sporadic colorectal adenomas were analysed for the presence of allelic loss on the short arm of chromosome 17 as well as mutations in the K-ras and p53 genes. Chromosome 17p13 allelic loss was not present in 14 out of 14 informative cases. K-ras mutations were observed in 15 out of 24 cases. A p53 gene mutation (GGC --> GAC at codon 245) was detected in two biopsies taken at a four year interval from a recurrent rectal villous adenoma. Both biopsies also contained the same K-ras gene mutation (GGT --> GTT at codon 12). The data from the recurrent rectal adenoma provide in vivo evidence that K-ras and p53 heterozygous mutations confer a proliferative advantage but together are not sufficient for malignant transformation.
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Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression / DE BENEDETTI, L; Varesco, L; Pellegata, Ns; Losi, Lorena; Gismondi, V; Casarino, L; Sciallero, S; Bonelli, L; Biticchi, R; Bafico, A; Masetti, E; James, R; Heouaine, A; Ranzani, Gn; Aste, H; Ferrara, G.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 13:(1993), pp. 667-670.
DE BENEDETTI, L; Varesco, L; Pellegata, Ns; Losi, Lorena; Gismondi, V; Casarino, L; Sciallero, S; Bonelli, L; Biticchi, R; Bafico, A; Masetti, E; James, R; Heouaine, A; Ranzani, Gn; Aste, H; Ferrara, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/611656
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