Many reports indicate that nonsteroidal anti-inflammatory drugs exert their antinociceptive effect through adrenergic and serotoninergic systems. We investigated the acute and chronic effects of phenazone on the pain threshold and on brain serotonin binding sites. A relationship between phenazone serum levels and the antinociceptive effect was found; acute treatment with phenazone provokes a significant decrease in serotonin binding sites both in the pons and cerebral cortex after 2, 4 and 8 h, but not after 24 h. After 15 and 30 days of treatment, the number of binding sites increases both in the pons and cortex.

Effects of chronic treatment with phenazone on the hot plate test and [3H]-Serotonin binding sites in pons and cortex membranes of the rat / Sandrini, Maurizio; Vitale, Giovanni; Pini, Luigi Alberto; E., Sternieri; Bertolini, Alfio. - In: PHARMACOLOGY. - ISSN 0031-7012. - STAMPA. - 47(1993), pp. 84-90.

Effects of chronic treatment with phenazone on the hot plate test and [3H]-Serotonin binding sites in pons and cortex membranes of the rat

SANDRINI, Maurizio;VITALE, Giovanni;PINI, Luigi Alberto;BERTOLINI, Alfio
1993

Abstract

Many reports indicate that nonsteroidal anti-inflammatory drugs exert their antinociceptive effect through adrenergic and serotoninergic systems. We investigated the acute and chronic effects of phenazone on the pain threshold and on brain serotonin binding sites. A relationship between phenazone serum levels and the antinociceptive effect was found; acute treatment with phenazone provokes a significant decrease in serotonin binding sites both in the pons and cerebral cortex after 2, 4 and 8 h, but not after 24 h. After 15 and 30 days of treatment, the number of binding sites increases both in the pons and cortex.
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84
90
Effects of chronic treatment with phenazone on the hot plate test and [3H]-Serotonin binding sites in pons and cortex membranes of the rat / Sandrini, Maurizio; Vitale, Giovanni; Pini, Luigi Alberto; E., Sternieri; Bertolini, Alfio. - In: PHARMACOLOGY. - ISSN 0031-7012. - STAMPA. - 47(1993), pp. 84-90.
Sandrini, Maurizio; Vitale, Giovanni; Pini, Luigi Alberto; E., Sternieri; Bertolini, Alfio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/611655
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