INTRODUCTION: Kaposi's Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who underwent liver transplantation (LT) between October 2000 and November 2006. METHODS: Patients were four males and two females. Mean age was 57 years (range 44-65). Indication for LT was ESLD associated/non-associated with hepatocellular carcinoma (HCC). The immunosuppressive regimen consisted of cyclosporine/tacrolimus associated with steroids or daclizumab. HHV8-detection was performed by the serological method before LT, and by polymerase chain reaction (PCR)-analysis after KS. RESULTS: One patient had HCV-related cirrhosis and coinfection from HIV, three had HBV-related cirrhosis, two of these with coexistent HCC. The last two patients had alcoholic-cirrhosis, one with coexistent HCC. Mean time from transplantation to KS was 6.2 months (range 3.8-8.8). Three patients were treated with doxorubicin and three with switch from calcineurin-inhibitors to sirolimus. Three patients expired after 11.5, 8.8, and 7.4 months from KS diagnosis. DISCUSSION: KS should be treated by a multidisciplinary approach to obtain an early diagnosis and best management. Effective treatment with immunosuppression reduction or switch to sirolimus is mandatory and can induce complete regression.
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|Data di pubblicazione:||2008|
|Titolo:||KAPOSI'S SARCOMA AFTER LIVER TRANSPLANTATION|
|Autori:||Di Benedetto F; Di Sandro S; De Ruvo N; Berretta M; Masetti M; Montalti R; Ballarin R; Cocchi S; Potenza L; Luppi M; Gerunda GE.|
|Autori interni:||GERUNDA, Giorgio Enrico |
DI BENEDETTO, Fabrizio
|Rivista:||JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY|
|Appare nelle tipologie:||Articolo su rivista|
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