Fifty-three patients with multiple myeloma (MM) underwent an allogeneic stem cell transplant (HSCT) from their HLA identical siblings using a reduced-intensity conditioning consisting of thiotepa 5 mg/kg, fludarabine 90 mg/m2, and melphalan 80 mg/m2. Their median age was 52 years (range 38 – 68) and the interval from diagnosis 12 months. Forty-three patients (82%) had advanced disease and 33 had previously been treated with high-dose therapy with one (N=21), or more (N=12) autologous transplants. Ten (18%) had their allograft programmed after induction chemotherapy. The majority (N=44) received peripheral blood as stem cell source. Acute graft-versus-host disease (GVHD) grade II – IV developed in 45%, but grade III – IV in only 5%. Cumulative incidence of chronic GVHD was 64%. Sixty-two per cent were in complete remission (CR) following transplantation. Transplant-related mortality was 13%. Relapse incidence was 32%. With a median follow-up of 22 months, 3-year overall survival is 45% and progression free survival (PFS) 37%. The thiotepa, fludarabine,and melphalan conditioning regimen can produce remissions in the majority of MM patients with a limited transplant mortality rate. When used as first line treatment the results of transplantation appear even more encouraging.
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|Anno di pubblicazione:||2007|
|Titolo:||Reduced intensity conditioning with thiotepa, fludarabine, and melphalan is effective in advanced multiple mieloma|
|Autori:||I. MAJOLINO; M. DAVOLI; E. CARNEVALLI; A. LOCASCIULLI; P. DI BARTOLOMEO; R. SCIMÈ; P. CORRADINI; C. SELLERI; F. NARNI; M. MUSSO; M. BREGNI; A. OLIVIERI; P. DE FABRITIIS; L. POGLIANI; J.E. DUQUE ARBELAEZ; C. RUSCIO; A. BACIGALUPO|
|Appare nelle tipologie:||Articolo su rivista|
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