BACKGROUND: Despite recognized risks associated with hyperphosphataemia in patients with chronic kidney disease (CKD) Stage 5 on dialysis, the achievement of target levels of serum phosphate is poor. It is likely that this is partly due to poor adherence by patients to their phosphate-binder treatment regimens, which often comprise large daily tablet burdens. METHODS: In this multicentre, open-label trial, patients on a stable dialysis regimen were screened while receiving phosphate-binder therapy, then entered into a washout phase. Patients with serum phosphate > 1.78 mmol/L after washout entered into the main 12-week treatment phase (N = 367), during which they were treated to target [Kidney Disease Outcomes Quality Initiative (K/DOQI)]: 1.13-1.78 mmol/L; 3.5-5.5 mg/dL) with lanthanum carbonate monotherapy. Efficacy variables included serum phosphate levels and the percentage of patients with serum phosphate control. Safety and tolerability assessments were also conducted. RESULTS: Mean serum phosphate levels were significantly reduced following 12 weeks of lanthanum carbonate monotherapy versus previous phosphate-binder therapy. The mean number of phosphate-binder tablets being taken per day at screening was 7.6, but during treatment with lanthanum carbonate, most patients were taking doses of up to 3000 mg/day, achievable with 3 x 1000 mg tablets per day (maximum of 6). CONCLUSION: These findings suggest that lanthanum carbonate monotherapy offers effective control of serum phosphate and, due to a low tablet burden, may help to simplify the management of hyperphosphataemia in patients with CKD Stage 5.
Switching to lanthanum carbonate monotherapy provides effective phosphate control with a low tablet burden / Hutchison, Aj; Laville, M; Albertazzi, Alberto; SPD LANTHANUM STUDY, Group. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - STAMPA. - 23 (11)(2008), pp. 3677-3684.
Data di pubblicazione: | 2008 |
Titolo: | Switching to lanthanum carbonate monotherapy provides effective phosphate control with a low tablet burden. |
Autore/i: | Hutchison, Aj; Laville, M; Albertazzi, Alberto; SPD LANTHANUM STUDY, Group |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 23 (11) |
Pagina iniziale: | 3677 |
Pagina finale: | 3684 |
Codice identificativo ISI: | WOS:000260153600046 |
Codice identificativo Scopus: | 2-s2.0-54149095265 |
Codice identificativo Pubmed: | 18577536 |
Citazione: | Switching to lanthanum carbonate monotherapy provides effective phosphate control with a low tablet burden / Hutchison, Aj; Laville, M; Albertazzi, Alberto; SPD LANTHANUM STUDY, Group. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - STAMPA. - 23 (11)(2008), pp. 3677-3684. |
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