EnglishMethane mono-oxygenase (MMO) and deoxyhemerythrin (DHr) are examples of di-iron enzymes that catalyze the dissociative and non-dissociative binding of molecular oxygen. To mimic the MMO active site with a finite cluster, we chose to study the binuclear heptapodate coordinated iron(III)-complexes of N,N,N,N'-tetrakis(2-benzimidazolylmethyl)-2-hydroxy-1,3-diamino-propane (HPTB) and N,N,N',N'-tetrakis(2-pyridylmethyl)-2-hydroxy-1,3-diamino-propane (HPTP). These have active sites of the form [Fez (HPTP)(mu -OH)](4+) (1) and [Fe-2(HPTB)(mu -OH)](4+) (2). Quantum mechanics structures are compared with the experimental data obtained from the EXAFS analysis. For the O-2 binding on the reduced active site. the mu-eta (1):eta (1)-O-2 mode seems the slightly more stable precursor to the O=Fe-O-Fe=O bis-ferryl (re)active site. The nature of the ferryl groups are these of a reactive two center three electron bond. (C) 2001 Elsevier Science B.V. All rights reserved.
| Data di pubblicazione: | 2001 |
| Titolo: | Reactivity of methane mono-oxygenase, insights from quantum mechanic studies on synthetic iron model complexex |
| Autore/i: | KNOPS GERRITS, P. P.; P. A., Jacobs; A., Fukuoka; M., Ichikawa; Faglioni, Francesco; W. A., GODDARD III |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | 10.1016/S1381-1169(00)00467-2 |
| Citazione: | Reactivity of methane mono-oxygenase, insights from quantum mechanic studies on synthetic iron model complexex / KNOPS GERRITS, P. P.; P. A., Jacobs; A., Fukuoka; M., Ichikawa; Faglioni, Francesco; W. A., GODDARD III. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - STAMPA. - 166(2001), pp. 3-13. |
| Tipologia | Relazione in Atti di Convegno |
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