BACKGROUND: Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic fatty liver disease (NAFLD). METHODS: In 114 subjects with NAFLD we report the prevalence and correlation with clinical parameters of three polymorphisms: interleukin-6 (-174G/C), plasma cell differentiation antigen (K121Q) and microsomal transfer protein (-493G/T). In 59 biopsied patients with NAFLD the polymorphisms were also related to histological features. RESULTS: IL-6 -174C variant was more prevalent (p<0.01) in NAFLD compared to controls. In the NAFLD group, C carriers had higher HOMA-IR and fasting insulin than G carriers (p<0.05). The prevalence of IL-6/C variant was higher (83%) in biopsied than in not biopsied subjects (66%) (p<0.05). In biopsied subjects, C carriers had higher HOMA and fasting insulin (p<0.05) compared than those with G allele. The prevalence of IL-6 -174G/C polymorphism was significantly higher in NASH than in NAFLD (p=0.048). At logistic regression analysis IL-6 -174C was an independent predictor of both NAFLD (OR 4.116, C.I. 1.126-15.048) and NASH (OR 7.035, C.I. 1.167-42.394). Conversely, the distribution of PC-1 and MTP polymorphisms was not significantly different compared to the control group, nor associated with clinical or histological characteristics. CONCLUSIONS: Our data suggest that IL-6 -174C genetic polymorphisms, involved in inflammation and insulin resistance, are associated with NASH. These data may contribute to the understanding of the genetic susceptibility to NAFLD.

Genetic polymorphisms in subjects with Non Alcoholic Fatty Liver Disease / Carulli, Lucia; Canedi, I; Rondinella, S; Lombardini, S; Ganazzi, Dorval; Fargion, S; DE PALMA, M; Lonardo, A; Ricchi, Matteo; Bertolotti, Marco; Carulli, Nicola; Loria, Paola. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - ELETTRONICO. - 41:11(2009), pp. 823-828. [10.1016/j.dld.2009.03.005]

Genetic polymorphisms in subjects with Non Alcoholic Fatty Liver Disease.

CARULLI, Lucia;GANAZZI, Dorval;RICCHI, Matteo;BERTOLOTTI, Marco;CARULLI, Nicola;LORIA, Paola
2009

Abstract

BACKGROUND: Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic fatty liver disease (NAFLD). METHODS: In 114 subjects with NAFLD we report the prevalence and correlation with clinical parameters of three polymorphisms: interleukin-6 (-174G/C), plasma cell differentiation antigen (K121Q) and microsomal transfer protein (-493G/T). In 59 biopsied patients with NAFLD the polymorphisms were also related to histological features. RESULTS: IL-6 -174C variant was more prevalent (p<0.01) in NAFLD compared to controls. In the NAFLD group, C carriers had higher HOMA-IR and fasting insulin than G carriers (p<0.05). The prevalence of IL-6/C variant was higher (83%) in biopsied than in not biopsied subjects (66%) (p<0.05). In biopsied subjects, C carriers had higher HOMA and fasting insulin (p<0.05) compared than those with G allele. The prevalence of IL-6 -174G/C polymorphism was significantly higher in NASH than in NAFLD (p=0.048). At logistic regression analysis IL-6 -174C was an independent predictor of both NAFLD (OR 4.116, C.I. 1.126-15.048) and NASH (OR 7.035, C.I. 1.167-42.394). Conversely, the distribution of PC-1 and MTP polymorphisms was not significantly different compared to the control group, nor associated with clinical or histological characteristics. CONCLUSIONS: Our data suggest that IL-6 -174C genetic polymorphisms, involved in inflammation and insulin resistance, are associated with NASH. These data may contribute to the understanding of the genetic susceptibility to NAFLD.
41
11
823
828
Genetic polymorphisms in subjects with Non Alcoholic Fatty Liver Disease / Carulli, Lucia; Canedi, I; Rondinella, S; Lombardini, S; Ganazzi, Dorval; Fargion, S; DE PALMA, M; Lonardo, A; Ricchi, Matteo; Bertolotti, Marco; Carulli, Nicola; Loria, Paola. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - ELETTRONICO. - 41:11(2009), pp. 823-828. [10.1016/j.dld.2009.03.005]
Carulli, Lucia; Canedi, I; Rondinella, S; Lombardini, S; Ganazzi, Dorval; Fargion, S; DE PALMA, M; Lonardo, A; Ricchi, Matteo; Bertolotti, Marco; Carulli, Nicola; Loria, Paola
File in questo prodotto:
File Dimensione Formato  
Carulli L Dig Liver Dis 2009_41_823-828.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 240.57 kB
Formato Adobe PDF
240.57 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/609599
Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 58
social impact