A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against Cryptococcus neoformans, in particular the regioisomer 4d (1.5 micrograms/ml).
Allylamine type xanthone antimycotics / I., Salmoiraghi; Rossi, Maddalena; P., Valenti; P., DA RE. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - STAMPA. - 331:(1998), pp. 225-227.
Allylamine type xanthone antimycotics
ROSSI, Maddalena;
1998
Abstract
A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against Cryptococcus neoformans, in particular the regioisomer 4d (1.5 micrograms/ml).
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