BACKGROUND: No study evaluates serum levels of CXCL10 and CCL2 chemokines in patients with hepatitis C associated mixed cryoglobulinaemia.AIMS: To measure circulating CXCL10 and CCL2 in cryoglobulinaemic patients.PATIENTS AND METHODS: Serum CXCL10 and CCL2 were assayed in 70 consecutive cryoglobulinaemic patients, and in 2 control groups (1:1, gender- and age-matched) of healthy (controls), or of chronic hepatitis C subjects without cryoglobulinaemia.RESULTS: Cryoglobulinaemic patients showed higher CXCL10 serum levels than controls (p<0.0001), or hepatitis C patients (p=0.001) (389 +/- 141, 91 +/- 51, 311 +/- 142 pg/ml, respectively). By defining a "high CXCL10" as a value at least 2 S.D. above the mean value of the control group (>193 pg/ml), 79% of cryoglobulinaemic patients, 5% of the controls and 69% of hepatitis C patients had high CXCL10 (p<0.0001). CXCL10 levels were (p<0.01) increased in cryoglobulinaemic patients with active vasculitis, with respect to those without (445+/-108, 339 +/- 161 pg/ml, respectively). Cryoglobulinaemic patients showed significantly higher CCL2 serum level than controls (p<0.01), but not than hepatitis C patients (541 +/- 493, 387 +/- 173 and 451 +/- 281 pg/ml, respectively).CONCLUSION: Our study first demonstrates high serum levels of CXCL10 and CCL2 chemokines in cryoglobulinaemic patients. Circulating CXCL10 is higher overall in cryoglobulinaemic patients with active vasculitis, suggesting a prevalence of the Th1 immune response in this phase.

CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C / A., Antonelli; Ferri, Clodoveo; P., Fallahi; Ferrari, Silvia Martina; S., Frascerra; F., Franzoni; F., Galetta; A. L., Zignego; E., Ferrannini. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 41:1(2009), pp. 42-48. [10.1016/j.dld.2008.04.009]

CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C.

FERRI, Clodoveo;FERRARI, Silvia Martina;
2009

Abstract

BACKGROUND: No study evaluates serum levels of CXCL10 and CCL2 chemokines in patients with hepatitis C associated mixed cryoglobulinaemia.AIMS: To measure circulating CXCL10 and CCL2 in cryoglobulinaemic patients.PATIENTS AND METHODS: Serum CXCL10 and CCL2 were assayed in 70 consecutive cryoglobulinaemic patients, and in 2 control groups (1:1, gender- and age-matched) of healthy (controls), or of chronic hepatitis C subjects without cryoglobulinaemia.RESULTS: Cryoglobulinaemic patients showed higher CXCL10 serum levels than controls (p<0.0001), or hepatitis C patients (p=0.001) (389 +/- 141, 91 +/- 51, 311 +/- 142 pg/ml, respectively). By defining a "high CXCL10" as a value at least 2 S.D. above the mean value of the control group (>193 pg/ml), 79% of cryoglobulinaemic patients, 5% of the controls and 69% of hepatitis C patients had high CXCL10 (p<0.0001). CXCL10 levels were (p<0.01) increased in cryoglobulinaemic patients with active vasculitis, with respect to those without (445+/-108, 339 +/- 161 pg/ml, respectively). Cryoglobulinaemic patients showed significantly higher CCL2 serum level than controls (p<0.01), but not than hepatitis C patients (541 +/- 493, 387 +/- 173 and 451 +/- 281 pg/ml, respectively).CONCLUSION: Our study first demonstrates high serum levels of CXCL10 and CCL2 chemokines in cryoglobulinaemic patients. Circulating CXCL10 is higher overall in cryoglobulinaemic patients with active vasculitis, suggesting a prevalence of the Th1 immune response in this phase.
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CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C / A., Antonelli; Ferri, Clodoveo; P., Fallahi; Ferrari, Silvia Martina; S., Frascerra; F., Franzoni; F., Galetta; A. L., Zignego; E., Ferrannini. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 41:1(2009), pp. 42-48. [10.1016/j.dld.2008.04.009]
A., Antonelli; Ferri, Clodoveo; P., Fallahi; Ferrari, Silvia Martina; S., Frascerra; F., Franzoni; F., Galetta; A. L., Zignego; E., Ferrannini
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/609462
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