EnglishChronic infection with hepatitis C virus (HCV) can result in both hepatic and extrahepatic disease and endocrine dysfunction represents an important class of HCV-related extrahepatic disease. The most frequently occurring--and clinically important--of these endocrine disorders are thyroid disease and type 2 diabetes mellitus. In this Review, we evaluate the evidence in support of a link between HCV infection and endocrine-system dysfunction, and discuss potential pathophysiological mechanisms. A meta-analysis of the literature has revealed significant associations between chronic HCV infection, thyroid autoimmunity and hypothyroidism. Furthermore, a high prevalence of thyroid cancer has been reported in HCV-positive patients. Several clinicoepidemiological studies have demonstrated that chronic HCV infection could lead to the development of type 2 diabetes mellitus, possibly as a result of HCV-induced metabolic disturbances. Some researchers have postulated that a type 1 T-helper -cell mediated immune response underpins the association of chronic HCV infection with endocrine disease. Indeed, the available data suggest that a common immunological, type 1 T-helper cell pattern of cytokine expression and activation (via interferon-gamma) could provide the pathophysiological basis for this association. Nonetheless, additional studies will be necessary to elucidate fully all the mechanisms involved in HCV-related endocrine dysfunction.
Endocrine manifestations of hepatitis C virus infection / A., Antonelli; Ferri, Clodoveo; Ferrari, Silvia Martina; Colaci, Michele; D., Sansonno; P., Fallahi. - In: NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM. - ISSN 1745-8366. - STAMPA. - 5:1(2009), pp. 26-34. [10.1038/ncpendmet1027]
| Data di pubblicazione: | 2009 | |
| Titolo: | Endocrine manifestations of hepatitis C virus infection. | |
| Autore/i: | A., Antonelli; Ferri, Clodoveo; Ferrari, Silvia Martina; Colaci, Michele; D., Sansonno; P., Fallahi | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/ncpendmet1027 | |
| Rivista: | ||
| Volume: | 5 | |
| Fascicolo: | 1 | |
| Pagina iniziale: | 26 | |
| Pagina finale: | 34 | |
| Codice identificativo ISI: | WOS:000261695600012 | |
| Codice identificativo Scopus: | 2-s2.0-57649165863 | |
| Codice identificativo Pubmed: | 19079271 | |
| Citazione: | Endocrine manifestations of hepatitis C virus infection / A., Antonelli; Ferri, Clodoveo; Ferrari, Silvia Martina; Colaci, Michele; D., Sansonno; P., Fallahi. - In: NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM. - ISSN 1745-8366. - STAMPA. - 5:1(2009), pp. 26-34. [10.1038/ncpendmet1027] | |
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