EnglishBACKGROUND: Mixed cryoglobulinaemia (MC), a systemic vasculitis associated with hepatitis C virus (HCV) infection in >90% of cases, is frequently complicated by multiple organ involvement. The prevalence of thyroid disorders in MC has not yet been studied.AIM: To investigate the prevalence and clinical features of thyroid involvement in patients with HCV-associated MC (HCV + MC).DESIGN: Case-control study.METHODS: HCV + MC patients (n = 93, 17 men and 76 women, mean +/- SD age 63 +/- 10 years, mean disease duration 14 +/- 7 years) consecutively referred to the Rheumatology Unit were matched by sex and age (+/- 2 years) to (i) 93 patients with chronic C hepatitis (CH) without MC and (ii) 93 healthy (HCV-negative) controls from the local population. Measurements included prevalence of hypo- or hyperthyroidism, thyroid autoantibodies, thyroid nodules and thyroid cancer.RESULTS: By McNemar's chi(2) test, the following thyroid abnormalities were significantly more frequent in HCV + MC patients than in HCV-negative controls: serum anti-thyroperoxidase autoantibody (AbTPO) (28% vs. 9%, p = 0.001); serum AbTPO and/or anti-thyroglobulin autoantibody (31% vs. 12%, p = 0.004); subclinical hypothyroidism (11% vs. 2%, p = 0.038); thyroid autoimmunity (35% vs. 16%, p = 0.006). Serum AbTPO were also significantly more frequent in HCV + MC patients than in CH controls (28% vs. 14%, p = 0.035).DISCUSSION: The prevalence of thyroid disorders is increased in patients with HCV-related mixed cryoglobulinaemia. We suggest careful monitoring of thyroid function in these patients.
Thyroid involvement in patients with overt HCV-related mixed cryoglobulinaemia / Antonelli, A; Ferri, Clodoveo; Fallahi, P; Giuggioli, D; Nesti, C; Longombardo, G; Fadda, P; Pampana, A; Maccheroni, M; Ferrannini, E.. - In: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. - ISSN 1460-2725. - STAMPA. - 97(2004), pp. 499-506.
| Data di pubblicazione: | 2004 |
| Titolo: | Thyroid involvement in patients with overt HCV-related mixed cryoglobulinaemia. |
| Autore/i: | Antonelli, A; Ferri, Clodoveo; Fallahi, P; Giuggioli, D; Nesti, C; Longombardo, G; Fadda, P; Pampana, A; Maccheroni, M; Ferrannini, E. |
| Autore/i UNIMORE: | |
| Rivista: | |
| Volume: | 97 |
| Pagina iniziale: | 499 |
| Pagina finale: | 506 |
| Codice identificativo ISI: | WOS:000222729100004 |
| Codice identificativo Scopus: | 2-s2.0-4344600903 |
| Codice identificativo Pubmed: | 15256607 |
| Citazione: | Thyroid involvement in patients with overt HCV-related mixed cryoglobulinaemia / Antonelli, A; Ferri, Clodoveo; Fallahi, P; Giuggioli, D; Nesti, C; Longombardo, G; Fadda, P; Pampana, A; Maccheroni, M; Ferrannini, E.. - In: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. - ISSN 1460-2725. - STAMPA. - 97(2004), pp. 499-506. |
| Tipologia | Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | |
|---|---|---|---|
| QJM.pdf | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia |
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
Copyright © 2021