Plasma B-Endorphin (B-EP), Growth Hormone (GH) and cortisol response to 100 mcg/m2 b.s., i.v. clonidine (an alpha 2-adrenergic agonist) were evaluated in 17 normal weight children (8 prepubertal and 9 pubertal) and in 15 children with simple exogenous obesity (7 prepubertal and 8 pubertal, weight excess ranging from 29% to 97%). All the hormones were measured by radioimmunoassay either directly in the plasma (GH and cortisol) or after extraction and chromatography (B-EP). Obese prepubertal and pubertal children showed basal B-EP levels significantly higher than in controls and no differences were found in GH and cortisol levels. While in controls clonidine stimulated a significant release of plasma GH and B-EP in obese patients, irrespective of pubertal development, no changes were found. Cortisol levels decreased in both groups. These data suggest an impaired adrenergic control of GH and B-EP secretion in children with simple exogenous obesity.
Absent B-Endorphin response to Clonidine in obese children / Facchinetti, Fabio; S., Bernasconi; F., Petraglia; C., Marcellini; Iughetti, Lorenzo; A. R., Genazzani. - In: HORMONE AND METABOLIC RESEARCH. - ISSN 0018-5043. - STAMPA. - 20(1988), pp. 348-351.
Data di pubblicazione: | 1988 |
Titolo: | Absent B-Endorphin response to Clonidine in obese children. |
Autore/i: | Facchinetti, Fabio; S., Bernasconi; F., Petraglia; C., Marcellini; Iughetti, Lorenzo; A. R., Genazzani |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 20 |
Pagina iniziale: | 348 |
Pagina finale: | 351 |
Codice identificativo ISI: | WOS:A1988P133800008 |
Codice identificativo Scopus: | 2-s2.0-0023892469 |
Codice identificativo Pubmed: | 2971010 |
Citazione: | Absent B-Endorphin response to Clonidine in obese children / Facchinetti, Fabio; S., Bernasconi; F., Petraglia; C., Marcellini; Iughetti, Lorenzo; A. R., Genazzani. - In: HORMONE AND METABOLIC RESEARCH. - ISSN 0018-5043. - STAMPA. - 20(1988), pp. 348-351. |
Tipologia | Articolo su rivista |
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