EnglishAIMS: To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1). METHODS: Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 +/- 4 years) with newly-diagnosed DM1 and 179 gender- and age-matched non-diabetic children. In 126 diabetic children, another blood sample was obtained 15 +/- 4 months after the diagnosis. RESULTS: Anti-CD38 autoantibody titers at least 3 SD above the mean value for the control group were found in 4.4% of children with DM1 vs 0.6% of controls (chi2 = 5.8, p <0.016). No statistical differences were observed between anti-CD38 positive and negative patients in terms of phenotype. At follow-up, of six diabetic children who were positive for anti-CD38 antibodies, two were new cases. A positive correlation was found between the antibody titer of diabetic sera at diagnosis and follow up (r = 0.46, p <0.0001). CONCLUSION: An autoimmune reaction against CD38, a protein expressed in human islets, is associated with newly-diagnosed DM1. In children with DM1, CD38 autoimmunity increases with time and persists.
| Data di pubblicazione: | 2005 |
| Titolo: | Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus. |
| Autore/i: | Pupilli, C; Antonelli, A; Iughetti, Lorenzo; D'Annunzio, G; Cotellessa, M; Vanelli, M; Okamoto, H; Lorini, R; Ferrannini, E. |
| Autore/i UNIMORE: | |
| Rivista: | |
| Volume: | 18 |
| Pagina iniziale: | 1417 |
| Pagina finale: | 1423 |
| Codice identificativo ISI: | WOS:000235123800008 |
| Codice identificativo Scopus: | 2-s2.0-30944446824 |
| Codice identificativo Pubmed: | 16459468 |
| Citazione: | Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus / Pupilli, C; Antonelli, A; Iughetti, Lorenzo; D'Annunzio, G; Cotellessa, M; Vanelli, M; Okamoto, H; Lorini, R; Ferrannini, E.. - In: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM. - ISSN 0334-018X. - STAMPA. - 18(2005), pp. 1417-1423. |
| Tipologia | Articolo su rivista |
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