We measured the angiopoietin-2 (Ang-2) expression in early chronic lymphocytic leukemia (CLL) patients, pointing our attention on the association with immunoglobulin (IgVH) mutational status, CD38 expression and clinical outcome. Our results indicate that Ang-2 expression is heterogeneous among Binet stage A CLL patients. CLL patients can be divided into two subgroups (Ang-2 positive and Ang-2 negative CLL) with 30% of them displaying Ang-2 RNA levels above the cut off. A shorter progression-free survival was observed in Ang-2 positive CLL subset (p = 0.032). Abnormal Ang-2 expression was also associated with unmutated IgVH genes (p < 0.0001) and increased bone marrow angiogenesis (p = 0.028), suggesting a role of Ang-2 in disease-progression of early CLL patients.
Increased expression of angiopoietin-2 characterizes early B-cell chronic lymphocytic leukemia with poor prognosis / Martinelli, Silvia; Maffei, Rossana; Castelli, Ilaria; Santachiara, R; Zucchini, Patrizia; Fontana, M; Bonacorsi, G; Leonardi, G; Marasca, Roberto; Torelli, Giuseppe. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 32:4(2008), pp. 593-597. [10.1016/j.leukres.2007.09.002]
Increased expression of angiopoietin-2 characterizes early B-cell chronic lymphocytic leukemia with poor prognosis
MARTINELLI, Silvia;MAFFEI, Rossana;CASTELLI, Ilaria;ZUCCHINI, Patrizia;MARASCA, Roberto;TORELLI, Giuseppe
2008
Abstract
We measured the angiopoietin-2 (Ang-2) expression in early chronic lymphocytic leukemia (CLL) patients, pointing our attention on the association with immunoglobulin (IgVH) mutational status, CD38 expression and clinical outcome. Our results indicate that Ang-2 expression is heterogeneous among Binet stage A CLL patients. CLL patients can be divided into two subgroups (Ang-2 positive and Ang-2 negative CLL) with 30% of them displaying Ang-2 RNA levels above the cut off. A shorter progression-free survival was observed in Ang-2 positive CLL subset (p = 0.032). Abnormal Ang-2 expression was also associated with unmutated IgVH genes (p < 0.0001) and increased bone marrow angiogenesis (p = 0.028), suggesting a role of Ang-2 in disease-progression of early CLL patients.
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