Prader-Willi syndrome (PWS), a genetic disorder due to an alteration in the paternally derived long arm of chromosome 15, is characterized by a complex clinical picture (short stature, obesity, hypogonadism) that seems to be referable to as a central hypothalamic/pituitary dysfunction. To determine whether there is any diminution in the anterior pituitary gland or other neuroradiological alterations, we retrospectively analysed 91 patients with PWS (42 females, 49 males; age range: 0.7–16.8 years) by cerebral magnetic resonance imaging (MRI). Of these 91 patients, MRI analysis showed a reduction in pituitary height in 45 patients (49.4%), a complete absence of the posterior pituitary bright spot in six patients (6.6%) and other neuroradiological alterations in ten patients (11%). Altogether, neuroradiological alterations were present in 61 of the 91 (67%) patients. Our results indicate that neuroradiological alterations are more frequent in PWS patients than has been reported to date

Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome / Iughetti, Lorenzo; Bosio, L; Corrias, A; Gargantini, L; Ragusa, L; Livieri, C; Predieri, Barbara; Bruzzi, Patrizia; Caselli, G; Grugni, G.. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - STAMPA. - 167:6(2008), pp. 701-702. [10.1007/s00431-007-0555-3]

Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome.

IUGHETTI, Lorenzo;PREDIERI, Barbara;BRUZZI, Patrizia;
2008

Abstract

Prader-Willi syndrome (PWS), a genetic disorder due to an alteration in the paternally derived long arm of chromosome 15, is characterized by a complex clinical picture (short stature, obesity, hypogonadism) that seems to be referable to as a central hypothalamic/pituitary dysfunction. To determine whether there is any diminution in the anterior pituitary gland or other neuroradiological alterations, we retrospectively analysed 91 patients with PWS (42 females, 49 males; age range: 0.7–16.8 years) by cerebral magnetic resonance imaging (MRI). Of these 91 patients, MRI analysis showed a reduction in pituitary height in 45 patients (49.4%), a complete absence of the posterior pituitary bright spot in six patients (6.6%) and other neuroradiological alterations in ten patients (11%). Altogether, neuroradiological alterations were present in 61 of the 91 (67%) patients. Our results indicate that neuroradiological alterations are more frequent in PWS patients than has been reported to date
2008
167
6
701
702
Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome / Iughetti, Lorenzo; Bosio, L; Corrias, A; Gargantini, L; Ragusa, L; Livieri, C; Predieri, Barbara; Bruzzi, Patrizia; Caselli, G; Grugni, G.. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - STAMPA. - 167:6(2008), pp. 701-702. [10.1007/s00431-007-0555-3]
Iughetti, Lorenzo; Bosio, L; Corrias, A; Gargantini, L; Ragusa, L; Livieri, C; Predieri, Barbara; Bruzzi, Patrizia; Caselli, G; Grugni, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/608668
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