Background: Laparoscopic splenectomy (LS) is considered the gold standard for the treatment ofhematologic disease of the spleen. Intraoperative bleeding is the main complication and main causeof conversion during LS. In this paper, we present our experience with 112 LS procedures, com-paring two different techniques and instruments for spleen dissection and hilar vascular control.Methods: We have performed a total of 112 LS procedures in 9 years in two affiliated universityhospitals. There were 48 males and 64 females (median age, 32.8 years). Indications were as follows:idiopathic thrombocytopenic purpura (ITP) in 42 patients, hereditary spherocitosis in 28, 6 with -talassemia, 1 with hemolitic anemia, 27 with lymphoma, 2 with leukemia, 3 with splenic cysts, and3 PPT cases. Associated procedures were present in 25 cases (17 cholecystectomy and 4 liver/lym-phnodal biopsies lysis of adhesions). Patients were divided in two groups according to the methodof dissection and hilar section (group 1, endostapler monopolar coagulation with 38 patients;group 2, the Ligasure™ Vessel Sealing System (Valleylab, Boulder, CO) with 74 patients).Results: Groups were well matched according to age, indications, spleen sizes, and procedures as-sociated. Conversion rates (10 cases, 9%; 5 in each group), postoperative hospital stay (median 4days in each group), and intra- and postoperative complications were similar in the 2 groups with-out any mortality in each group, while intraoperative blood loss (loss of 100 mL in 55 patients ingroup 2, 78%; and in 21 patients in group 1, 52%), transfusion rates (8 patients in group 1 versus4 patients in group 2), and operative mean time (150 minutes in group 1 versus 125 minutes in group2) were minor in the Ligasure Vessel Sealing System group, with a statistical significance.Conclusions: The approach to spleen dissection and hilum section was safe and efficacy in eachcase, otherwise the use of Ligasure results in a gain of time. Furthermore the average intraopera-tive bleeding and average transfusion rates of this series were lower in group 2.