This paper addresses an important combination of three-dimensional loading and vehicle routing, known as the Three-Dimensional Loading Capacitated Vehicle Routing Problem. The problem calls for the combined optimization of the loading of freight into vehicles and the routing of vehicles along a road network, with the aim of serving customers with minimum traveling cost. Despite its clear practical relevance in freight distribution, the literature on this problem is very limited. This is because of its high combinatorial complexity.We solve the problem by means of an Ant Colony Optimization algorithm, which makes use of fast packing heuristics for the loading. The algorithm combines two different heuristic information measures, one for routing and one for packing. In numerical tests all publicly available test instances are solved, andfor almost all instances new best solutions are found.