Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration

Trenti, T; Bertolotti, Marco; Castellana, Cn; Ferrari, Anna; Pini, Luigi Alberto; Sternieri, Emilio

Since plasma reduced glutathione (GSH) seems to reflect liver GSH content, we have assessed plasma GSH in patients using paracetamol daily. In these patients a significant lower plasma GSH concentration was found with respect to controls. After the i.v. administration of GSH free plasma cysteine was 12 fold higher than in basal condition and all the pattern of plasma thiol groups was modified. This work suggests that the possible protective effect of GSH administration is due to the availability of plasma thiol compounds that enter the cell rather than GSH itself.

Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration / Trenti, T; Bertolotti, Marco; Castellana, Cn; Ferrari, Anna; Pini, Luigi Alberto; Sternieri, Emilio. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - STAMPA. - 64/65(1992), pp. 757-761.

Data di pubblicazione:	1992
Titolo:	Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration
Autore/i:	Trenti, T; Bertolotti, Marco; Castellana, Cn; Ferrari, Anna; Pini, Luigi Alberto; Sternieri, Emilio
Autore/i UNIMORE:	TRENTI T BERTOLOTTI, Marco CASTELLANA CN FERRARI, Anna PINI, Luigi Alberto STERNIERI, Emilio mostra contributor esterni nascondi contributor esterni
Rivista:	TOXICOLOGY LETTERS
Volume:	64/65
Pagina iniziale:	757
Pagina finale:	761
Codice identificativo ISI:	WOS:A1992KE52600093
Codice identificativo Scopus:	2-s2.0-0026749554
Codice identificativo Pubmed:	1471232
Citazione:	Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration / Trenti, T; Bertolotti, Marco; Castellana, Cn; Ferrari, Anna; Pini, Luigi Alberto; Sternieri, Emilio. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - STAMPA. - 64/65(1992), pp. 757-761.
Tipologia	Articolo su rivista

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http://hdl.handle.net/11380/608015

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