The treatment of bladder cancer with Bacillus of Calmette-Guerin (BCG) immunotherapy can induce the appearance of a reactive disorder. The Authors describe a 55-year-old male patient with bladder cancer treated with endovesical instillation of BCG immunotherapy, followed after the fifth application by asymmetric oligoarthritis and dactilitis. The observed positivity of both HLA-B27 and HLA-B51 antigens reinforces the hypothesis of a reactive form, possibly through "molecular mimicry" mechanism. The discontinuation of BCG instillation along which a therapeutic attempt with NSAD failed to improve the rheumatic manifestation, which completely remitted after a four-month course of oral steroids. No relapses of joint and tendon involvement was observed during the following five-month period. The clinico-pathogenetic implications suggested by this case are discussed.

Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer / Manzini, Cu; Bernini, L; Elkhaldi, N; Mascia, Maria Teresa; Ferri, Clodoveo. - In: REUMATISMO. - ISSN 0048-7449. - STAMPA. - 58(3)(2006), pp. 230-232.

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