The treatment of bladder cancer with Bacillus of Calmette-Guerin (BCG) immunotherapy can induce the appearance of a reactive disorder. The Authors describe a 55-year-old male patient with bladder cancer treated with endovesical instillation of BCG immunotherapy, followed after the fifth application by asymmetric oligoarthritis and dactilitis. The observed positivity of both HLA-B27 and HLA-B51 antigens reinforces the hypothesis of a reactive form, possibly through "molecular mimicry" mechanism. The discontinuation of BCG instillation along which a therapeutic attempt with NSAD failed to improve the rheumatic manifestation, which completely remitted after a four-month course of oral steroids. No relapses of joint and tendon involvement was observed during the following five-month period. The clinico-pathogenetic implications suggested by this case are discussed.
Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer / Manzini, Cu; Bernini, L; Elkhaldi, N; Mascia, Maria Teresa; Ferri, Clodoveo. - In: REUMATISMO. - ISSN 0048-7449. - STAMPA. - 58(3)(2006), pp. 230-232.
Data di pubblicazione: | 2006 |
Titolo: | Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer |
Autore/i: | Manzini, Cu; Bernini, L; Elkhaldi, N; Mascia, Maria Teresa; Ferri, Clodoveo |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 58(3) |
Pagina iniziale: | 230 |
Pagina finale: | 232 |
Codice identificativo Scopus: | 2-s2.0-33748995949 |
Codice identificativo Pubmed: | 17013441 |
Citazione: | Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer / Manzini, Cu; Bernini, L; Elkhaldi, N; Mascia, Maria Teresa; Ferri, Clodoveo. - In: REUMATISMO. - ISSN 0048-7449. - STAMPA. - 58(3)(2006), pp. 230-232. |
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