Primary intrapulmonary thymomas (PITs) are very uncommon,with 28 cases reported to date.1-3 Because ofthe paucity of studies, the biologic behavior and pathologicfeatures of these neoplasms are not well known.The C677T methylenetetrahydrofolate reductase (MTHFR) genotypeis a congenital disorder leading to low folate levels; theresultant mild hyperhomocysteinemia is associated with increasedrisk of venous thromboembolism and malignancies.4,5We present a case of PIT associated with hyperhomocysteinemiacaused by the C677T variant of MTHFR.
Primary intrapulmonary thymoma associated with congenital hyperhomocysteinemia / Stefani, Alessandro; E., Boulenger; S., Mehaut; A., Ciupea; M., Alifano. - In: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY. - ISSN 0022-5223. - STAMPA. - 134:3(2007), pp. 799-801. [10.1016/j.jtcvs.2007.03.052]
Primary intrapulmonary thymoma associated with congenital hyperhomocysteinemia.
STEFANI, Alessandro;
2007
Abstract
Primary intrapulmonary thymomas (PITs) are very uncommon,with 28 cases reported to date.1-3 Because ofthe paucity of studies, the biologic behavior and pathologicfeatures of these neoplasms are not well known.The C677T methylenetetrahydrofolate reductase (MTHFR) genotypeis a congenital disorder leading to low folate levels; theresultant mild hyperhomocysteinemia is associated with increasedrisk of venous thromboembolism and malignancies.4,5We present a case of PIT associated with hyperhomocysteinemiacaused by the C677T variant of MTHFR.
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