Effects of serum from pregnant women on basal and FSH (or cAMP) stimulated aromatase activity of immature rat Sertoli cells in primary culture were studied. Pregnancy serum caused a dose-dependent stimulation of Sertoli cell aromatase activity and the response curves were parallel to those obtained with human FSH. This stimulatory (FSH-like) activity increased progressively during pregnancy, with a sharp drop immediately after delivery. However, the FSH-like bioactivity was not associated with immunoreactive FSH when a specific radioimmunoassay was employed. On the other hand, serum from pregnant women caused a dose-dependent inhibition of FSH and dibutyryl-cAMP-stimulated aromatase activity. These data suggest that human pregnancy serum contains factor(s) which may stimulate basal aromatase activity of Sertoli cells and may inhibit FSH-induced aromatase activity. These factors, most probably of placental origin, may play a role in the regulation of estrogen production during gestation.

Stimulatory and inhibitory influences of serum from pregnant women on aromatase activity of immature rat Sertoli cells / Simoni, Manuela; Khan, Sa; DE GEYTER, Ch; Nieschlag, E.. - In: ACTA ENDOCRINOLOGICA. - ISSN 0001-5598. - ELETTRONICO. - 121:(1989), pp. 265-269.

Stimulatory and inhibitory influences of serum from pregnant women on aromatase activity of immature rat Sertoli cells.

SIMONI, Manuela;
1989

Abstract

Effects of serum from pregnant women on basal and FSH (or cAMP) stimulated aromatase activity of immature rat Sertoli cells in primary culture were studied. Pregnancy serum caused a dose-dependent stimulation of Sertoli cell aromatase activity and the response curves were parallel to those obtained with human FSH. This stimulatory (FSH-like) activity increased progressively during pregnancy, with a sharp drop immediately after delivery. However, the FSH-like bioactivity was not associated with immunoreactive FSH when a specific radioimmunoassay was employed. On the other hand, serum from pregnant women caused a dose-dependent inhibition of FSH and dibutyryl-cAMP-stimulated aromatase activity. These data suggest that human pregnancy serum contains factor(s) which may stimulate basal aromatase activity of Sertoli cells and may inhibit FSH-induced aromatase activity. These factors, most probably of placental origin, may play a role in the regulation of estrogen production during gestation.
121
265
269
Stimulatory and inhibitory influences of serum from pregnant women on aromatase activity of immature rat Sertoli cells / Simoni, Manuela; Khan, Sa; DE GEYTER, Ch; Nieschlag, E.. - In: ACTA ENDOCRINOLOGICA. - ISSN 0001-5598. - ELETTRONICO. - 121:(1989), pp. 265-269.
Simoni, Manuela; Khan, Sa; DE GEYTER, Ch; Nieschlag, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/607722
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