Aim: To assess for the first time the occurrence of Y chromosomal microdeletions and partial deletions of the Azoospermia Factor c (AZFc) region in Sri Lankan men and to correlate them with clinical parameters.Methods: In a retrospective study, we analyzed 96 infertile men (78 with non-obstructive azoospermia) and 87 controls with normal spermatogenesis. AZFa, AZFb, AZFc and partial deletions within the AZFc region were analyzed by multiplex polymerase chain reaction (PCR) according to established protocols.Results: No AZFa, AZFb or AZFc deletions were found in the control group. Seven patients in the group of infertile men were found to have deletions as following: one AZFa, two AZFc, two AZFbc and two AZFabc. The relative distribution of these patterns was significantly different compared with that found in the German population. Extension analysis confirmed that the deletions occurred according to the current pathogenic model. gr/gr deletions were found to be equally present both in the patients (n= 4) and in the control group (n= 4). One b2/b3 deletion was found in the patient group.Conclusion: These results suggest that the frequency and pattern of microdeletions of the Y chromosome in Sri Lankan men are similar to those found in other populations and confirm that gr/gr deletions are not sufficient to cause spermatogenetic failure.
|Data di pubblicazione:||2006|
|Titolo:||Y-chromosomal microdeletions and partial deletions of the AZFc region in normozoospermic, severe oligozoospermic and azoospermic men from Sri Lanka.|
|Autore/i:||Fernando, L; Gromoll, J; Weerasooriya, Tr; Nieschlag, E; Simoni, Manuela|
|Digital Object Identifier (DOI):||10.1111/j.1745-7262.2006.00100.x|
|Codice identificativo ISI:||WOS:000234608900004|
|Codice identificativo Scopus:||2-s2.0-30444460100|
|Codice identificativo Pubmed:||16372117|
|Citazione:||Y-chromosomal microdeletions and partial deletions of the AZFc region in normozoospermic, severe oligozoospermic and azoospermic men from Sri Lanka / Fernando, L; Gromoll, J; Weerasooriya, Tr; Nieschlag, E; Simoni, Manuela. - In: ASIAN JOURNAL OF ANDROLOGY. - ISSN 1008-682X. - ELETTRONICO. - 8(2006), pp. 39-44.|
|Tipologia||Articolo su rivista|
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris