BACKGROUND: In mice, anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment and decreases FSH sensitivity. Little is known about the role of AMH in human ovarian physiology. We hypothesize that in women AMH has a similar role in ovarian function as in mice and investigated this using a genetic approach.METHODS: The association of the AMH Ile49Ser and the AMH type II receptor (AMHR2) –482 A > G polymorphisms with menstrual cycle characteristics was studied in a Dutch (n = 32) and a German (n = 21) cohort of normo-ovulatory women.RESULTS: Carriers of the AMH Ser49 allele had higher serum estradiol (E2) levels on menstrual cycle day 3 when compared with non-carriers in the Dutch cohort (P = 0.012) and in the combined Dutch and German cohort (P = 0.03). Carriers of the AMHR2 –482G allele also had higher follicular phase E2 levels when compared with non-carriers in the Dutch cohort (P = 0.028), the German cohort (P = 0.048) and hence also the combined cohort (P = 0.012). Women carrying both AMH Ser49 and AMHR2 –482G alleles had highest E2 levels (P = 0.001). For both polymorphisms no association with serum AMH or FSH levels was observed.CONCLUSIONS: Polymorphisms in the AMH and AMHR2 genes are associated with follicular phase E2 levels, suggesting a role for AMH in the regulation of FSH sensitivity in the human ovary.
|Data di pubblicazione:||2007|
|Titolo:||AMH AND AMH TYPE II RECEPTOR POLYMORPHISMS ARE ASSOCIATED WITH FOLLICULAR PHASE ESTRADIOL LEVELS IN NORMO-OVULATORY WOMEN.|
|Autori:||KEVENAAR ME; THEMMEN APN; LAVEN JSE; SONNTAG B; FONG SL; UITTERLINDEN AG; DE JONG FH; POLS HAP; M. SIMONI; VISSER JA|
|Digital Object Identifier (DOI):||10.1093/humrep/dem036|
|Appare nelle tipologie:||Articolo su rivista|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris