Preliminary behavioral experiments in rats with thecannabinoid agonist HU 210 (12.5–100mg/kg IP) showed that it has a potent cannabimimetic profile similar to that ofD9THC;the drug dose dependently depressed locomotor activity, rearing, and grooming and elicited vocalization and circling at thehighest doses. In subsequent studies on pigeons, HU 210 (12.5–50mg/kg SC) confirmed its sedative effects; it also affordedprotection against vomiting induced by cisplatin (7.5 mg/kg IV) and emetine (20 mg/kg SC) and emetine-induced headshake.
Cannabimimetic activity in rats and pigeons of HU 210, a potent antiemetic drug / Ferrari, Francesca; Ottani, Alessandra; Giuliani, Daniela. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 62:(1999), pp. 75-80.
Cannabimimetic activity in rats and pigeons of HU 210, a potent antiemetic drug
FERRARI, Francesca;OTTANI, Alessandra;GIULIANI, Daniela
1999
Abstract
Preliminary behavioral experiments in rats with thecannabinoid agonist HU 210 (12.5–100mg/kg IP) showed that it has a potent cannabimimetic profile similar to that ofD9THC;the drug dose dependently depressed locomotor activity, rearing, and grooming and elicited vocalization and circling at thehighest doses. In subsequent studies on pigeons, HU 210 (12.5–50mg/kg SC) confirmed its sedative effects; it also affordedprotection against vomiting induced by cisplatin (7.5 mg/kg IV) and emetine (20 mg/kg SC) and emetine-induced headshake.
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