This work aims to assay in humans the intragastric behaviour of an air compartment multiple unit delivery system able to float just placed into the gastric fluid and obtainable by a new simple technological approach. The floating system used in this study had shown an excellent buoyancy ability in a previous "in vitro" investigation (3). The "in vivo" floating time and the gastric residence time (GRT) of the floating system were determined by X-ray photographs and compared with those of a non-floating system in both fasted and fed states.
Intragastric behaviour of a multiple unit floating system / Iannuccelli, Valentina; Coppi, Gilberto; Cameroni, Riccardo. - STAMPA. - 24:(1997), pp. 403-404. (Intervento presentato al convegno 24th International Symposium on Controlled Release of Bioactive Materials tenutosi a Stoccolma - Svezia nel 15-19 giugno 1997).
Intragastric behaviour of a multiple unit floating system
IANNUCCELLI, Valentina;COPPI, Gilberto;CAMERONI, Riccardo
1997
Abstract
This work aims to assay in humans the intragastric behaviour of an air compartment multiple unit delivery system able to float just placed into the gastric fluid and obtainable by a new simple technological approach. The floating system used in this study had shown an excellent buoyancy ability in a previous "in vitro" investigation (3). The "in vivo" floating time and the gastric residence time (GRT) of the floating system were determined by X-ray photographs and compared with those of a non-floating system in both fasted and fed states.
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