A tumor is a complex framework composed of tumor cells (TC) and stroma where the extracellular matrix (ECM) and cellular components such as immune cells, vessels cells and fibroblasts interact closely together. Here these complex interactions are addressed in the light of the possible use of mesenchymal stomal cells to target tumors.

A TRAIL delivery approach has been performed by our group and, for the first time, stably transducer stem cells expressing-TRAIL showed a strong cytotoxic effect against human cervical carcinoma in vivo.105 We demonstrate the efficiency of TRAIL and its secretable forms in the inhibition of tumor cell growth suggesting that, despite the still unclear role of MSCs in influencing tumor cell growth, these cells can be translated from the regenerative medicine to specifically target cancer.

Mesenchymal Stromal/Stem Cells from Tissue Repair to Destruction of Tumor Cells / Bussolari, Rita; Grisendi, Giulia; L., Cafarelli; Loschi, Pietro; L., Scarabelli; A., Frassoldati; M., Maur; DE SANTIS, Giorgio; Paolucci, Paolo; P. F., Conte; Dominici, Massimo. - STAMPA. - (2011), pp. 141-158. [10.1039/9781849732246-00141]

Mesenchymal Stromal/Stem Cells from Tissue Repair to Destruction of Tumor Cells

BUSSOLARI, Rita;GRISENDI, Giulia;LOSCHI, Pietro;DE SANTIS, Giorgio;PAOLUCCI, Paolo;DOMINICI, Massimo
2011

Abstract

A tumor is a complex framework composed of tumor cells (TC) and stroma where the extracellular matrix (ECM) and cellular components such as immune cells, vessels cells and fibroblasts interact closely together. Here these complex interactions are addressed in the light of the possible use of mesenchymal stomal cells to target tumors.
3-dic-2010
Stem cell-based tissue repair
1849732248
9781849730013
9781849732246
Royal Society of Chemistry
REGNO UNITO DI GRAN BRETAGNA
Mesenchymal Stromal/Stem Cells from Tissue Repair to Destruction of Tumor Cells / Bussolari, Rita; Grisendi, Giulia; L., Cafarelli; Loschi, Pietro; L., Scarabelli; A., Frassoldati; M., Maur; DE SANTIS, Giorgio; Paolucci, Paolo; P. F., Conte; Dominici, Massimo. - STAMPA. - (2011), pp. 141-158. [10.1039/9781849732246-00141]
Bussolari, Rita; Grisendi, Giulia; L., Cafarelli; Loschi, Pietro; L., Scarabelli; A., Frassoldati; M., Maur; DE SANTIS, Giorgio; Paolucci, Paolo; P. F., Conte; Dominici, Massimo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/606013
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