Duchenne muscular dystrophy yields pervasive and progressive muscle mass loss. In the current measures relating to the monitoring of disease progression the following are relevant (i): the type of scale used, (ii) the clinical significance of the attribute being measured and (iii) the mathematical properties of the data provided. The high prevalence of obesity at an early stage of this pathology could result not only from reduced physical activity, but also from low resting energy expenditure, abnormal nutrient utilization or overfeeding. This muscle weakness may be attenuated by regular low-intensity exercise. However, there is a critical lack of data to support appropriate exercise prescription. Because inappropriate activity may exacerbate the dystrophic process, a systematic analysis of muscle function to determine potential exercise load thresholds to avoid injury in dystrophic mice and dogs, and then in humans is recommended.

Duchenne muscle activity evaluation and muscle function preservation: is it possible a prophylactic strategy? / Palmieri, Beniamino; V., Sbendorio; Ferrari, Adriano; A., Pietrobelli. - In: OBESITY. - ISSN 1930-7381. - STAMPA. - 9:2(2008), pp. 121-139. [10.1111/j.1467-789X.2007.00423.x]

Duchenne muscle activity evaluation and muscle function preservation: is it possible a prophylactic strategy?

PALMIERI, Beniamino;FERRARI, Adriano;
2008

Abstract

Duchenne muscular dystrophy yields pervasive and progressive muscle mass loss. In the current measures relating to the monitoring of disease progression the following are relevant (i): the type of scale used, (ii) the clinical significance of the attribute being measured and (iii) the mathematical properties of the data provided. The high prevalence of obesity at an early stage of this pathology could result not only from reduced physical activity, but also from low resting energy expenditure, abnormal nutrient utilization or overfeeding. This muscle weakness may be attenuated by regular low-intensity exercise. However, there is a critical lack of data to support appropriate exercise prescription. Because inappropriate activity may exacerbate the dystrophic process, a systematic analysis of muscle function to determine potential exercise load thresholds to avoid injury in dystrophic mice and dogs, and then in humans is recommended.
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Duchenne muscle activity evaluation and muscle function preservation: is it possible a prophylactic strategy? / Palmieri, Beniamino; V., Sbendorio; Ferrari, Adriano; A., Pietrobelli. - In: OBESITY. - ISSN 1930-7381. - STAMPA. - 9:2(2008), pp. 121-139. [10.1111/j.1467-789X.2007.00423.x]
Palmieri, Beniamino; V., Sbendorio; Ferrari, Adriano; A., Pietrobelli
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/597859
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