In vitro tests are very powerful methods to assess the carcinogenic effects of different substances and to study the initial phases of tumor development. A CA model of the formation of transformation foci in cell cultures which are exposed to a carcinogen is presented here, based on known facts about carcinogenesis and about reasonable assumptions, which gives rise to a cell growth dynamics similar to the one experimentally observed. The model can be used to test formal hypotheses about different interfering phenomena and about their relative strength
A cellular automata model for the simulation of in vitro carcinogenesis tests / Serra, Roberto; Villani, Marco; A., Colacci. - STAMPA. - (2001), pp. 135-143. (Intervento presentato al convegno Acri200 - the Fourth International Conference on Cellular Automata for Research and Industry tenutosi a Karlsruhe nel October 04 - 06).
A cellular automata model for the simulation of in vitro carcinogenesis tests
SERRA, Roberto;VILLANI, Marco;
2001
Abstract
In vitro tests are very powerful methods to assess the carcinogenic effects of different substances and to study the initial phases of tumor development. A CA model of the formation of transformation foci in cell cultures which are exposed to a carcinogen is presented here, based on known facts about carcinogenesis and about reasonable assumptions, which gives rise to a cell growth dynamics similar to the one experimentally observed. The model can be used to test formal hypotheses about different interfering phenomena and about their relative strength
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