The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
A novel class of allosteric modulators of AMPA/Kainate receptors / Cannazza, Giuseppe; Krzysztof, Jozwiak; Parenti, Carlo; Braghiroli, Daniela; Carrozzo, Marina Maria; Puja, Giulia; Losi, Gabriele; Baraldi, Mario; Wolfgang, Lindner; Irving W., Wainer. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 19:4(2009), pp. 1254-1257. [10.1016/j.bmcl.2008.12.094]
A novel class of allosteric modulators of AMPA/Kainate receptors
CANNAZZA, Giuseppe;PARENTI, Carlo;BRAGHIROLI, Daniela;CARROZZO, Marina Maria;PUJA, Giulia;LOSI, Gabriele;BARALDI, Mario;
2009
Abstract
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
| File | Dimensione | Formato | |
|---|---|---|---|
|
A novel class of allosteric modulators of AMPA.pdf
Accesso riservato
Tipologia:
Versione pubblicata dall'editore
Dimensione
317.23 kB
Formato
Adobe PDF
|
317.23 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
