We recently found a number of intermediate DYS458 alleles, indicated as .2. This allelic variant is distributed in several populations, but currently no information is available regarding the molecular structure and the genealogical correlation of chromosomes with this variant. The molecular characterisation of such allele, its worldwide distribution and the correlated evolutionary history are the subject of the present paper. Molecular and genealogical data are suggestive of a single origin for the .2 variant. Phylogeographic analysis points to either a Middle East or East African origin, but additional data is necessary to clarify this point. Our results suggest that the .2 variants is a stable polymorphism and that it could be used for population studies.

Molecular characterisation and population genetics of the DYS458 .2 allelic variant. 22st / Ferri, Gianmarco; C., Robino; Alu', Milena; D., Luiselli; S., Tofanelli; L., Caciagli; V., Onofri; S., Pelotti; C., Di Gaetano; F., Crobu; Beduschi, Giovanni; C., Capelli. - In: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES. - ISSN 1875-1768. - STAMPA. - 1:(2008), pp. 203-205.

Molecular characterisation and population genetics of the DYS458 .2 allelic variant. 22st

FERRI, Gianmarco;ALU', Milena;BEDUSCHI, Giovanni;
2008

Abstract

We recently found a number of intermediate DYS458 alleles, indicated as .2. This allelic variant is distributed in several populations, but currently no information is available regarding the molecular structure and the genealogical correlation of chromosomes with this variant. The molecular characterisation of such allele, its worldwide distribution and the correlated evolutionary history are the subject of the present paper. Molecular and genealogical data are suggestive of a single origin for the .2 variant. Phylogeographic analysis points to either a Middle East or East African origin, but additional data is necessary to clarify this point. Our results suggest that the .2 variants is a stable polymorphism and that it could be used for population studies.
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Molecular characterisation and population genetics of the DYS458 .2 allelic variant. 22st / Ferri, Gianmarco; C., Robino; Alu', Milena; D., Luiselli; S., Tofanelli; L., Caciagli; V., Onofri; S., Pelotti; C., Di Gaetano; F., Crobu; Beduschi, Giovanni; C., Capelli. - In: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES. - ISSN 1875-1768. - STAMPA. - 1:(2008), pp. 203-205.
Ferri, Gianmarco; C., Robino; Alu', Milena; D., Luiselli; S., Tofanelli; L., Caciagli; V., Onofri; S., Pelotti; C., Di Gaetano; F., Crobu; Beduschi, Giovanni; C., Capelli
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/596426
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