D2R–striatopallidal neurons inhibit both locomotor and drug reward processes

The striatum is involved in motor and motivational control but the specific functions of D2R–striatopallidal (dopamine D2 receptor–positive) neurons remain poorly understood. Using a genetic mouse model, we showed that ablation of D2R–striatopallidal neurons in the entire striatum induces hyperlocomotion while ablation in the ventral striatum increases amphetamine conditioned place preference. These results demonstrate the motor inhibitory role of D2R–striatopallidal neurons and an involvement in limiting the drug–reinforcement.