A development of a rapid and sensitive LC–MS/MS method for the simultaneous detection of active ingredients of the euthanasic veterinarian drug Tanax® mixture is described.The method proposed, with a retention time of few minutes (6 min) was developed for an equine serum sample with solid-phase extraction (S.P.E). This S.P.E. procedure has been revealed useful for the determination of very low concentrations of Tanax® analytes (0.05–1 ng/ml).The method was validated in terms of specificity/selectivity, sensitivity, recovery and precision.
Development of a liquid chromatography–tandem mass spectrometry method for an euthanasic veterinarian drug: Tanax® / M., Fidani; Gamberini, Maria Cristina; E., Pasello; Palazzoli, Federica; T., Dimasi; M., Montana. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 48:3(2008), pp. 902-908. [10.1016/j.jpba.2008.07.024]
Development of a liquid chromatography–tandem mass spectrometry method for an euthanasic veterinarian drug: Tanax®
GAMBERINI, Maria Cristina;PALAZZOLI, Federica;
2008
Abstract
A development of a rapid and sensitive LC–MS/MS method for the simultaneous detection of active ingredients of the euthanasic veterinarian drug Tanax® mixture is described.The method proposed, with a retention time of few minutes (6 min) was developed for an equine serum sample with solid-phase extraction (S.P.E). This S.P.E. procedure has been revealed useful for the determination of very low concentrations of Tanax® analytes (0.05–1 ng/ml).The method was validated in terms of specificity/selectivity, sensitivity, recovery and precision.
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