Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.
Apoptosis: Escaping strategies in human skin cancer (Review) / Giannetti, Luca; Consolo, Ugo; Magnoni, Cristina; Lorenzo Lo, Muzio. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - STAMPA. - 11:2(2004), pp. 401-405. [10.3892/or.11.2.401]
Apoptosis: Escaping strategies in human skin cancer (Review)
GIANNETTI, Luca;CONSOLO, Ugo;MAGNONI, Cristina;
2004
Abstract
Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.
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