Damage to mitochondria (mt) is a major side effect of highly active antiretroviral therapy (HAART) tha includes a nucleoside reverse transcriptase inhibitor (NRTI).Such damage is associated with the onset of lipodystrophy in HAART-treated HIV+ patients. To further investigate mt changes during this syndrome, we analysed the expression of mtRNA in adipocytes from lipodystrophic HIV+ patients taking NRTI-containing HAART and compared it with similar cells from healthy individuals.
Altered mithocondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy / Galluzzi, L.; Pinti, Marcello; Guaraldi, Giovanni; Mussini, Cristina; Troiano, L.; Roat, E.; Giovenzana, C.; Nemes, E.; Nasi, M.; Orlando, G.; Salomoni, P.; Cossarizza, Andrea. - In: ANTIVIRAL THERAPY. - ISSN 1359-6535. - STAMPA. - 10 (2):(2005), pp. M91-M99. (Intervento presentato al convegno 1st Meeting on Mithocondrial toxicity and HIV Infection: Understanding the pathogenesis for a therapeutic approach tenutosi a Modena -Italy nel 19-21/05/2005).
Altered mithocondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy
PINTI, Marcello;GUARALDI, Giovanni;MUSSINI, Cristina;M. Nasi;COSSARIZZA, Andrea
2005
Abstract
Damage to mitochondria (mt) is a major side effect of highly active antiretroviral therapy (HAART) tha includes a nucleoside reverse transcriptase inhibitor (NRTI).Such damage is associated with the onset of lipodystrophy in HAART-treated HIV+ patients. To further investigate mt changes during this syndrome, we analysed the expression of mtRNA in adipocytes from lipodystrophic HIV+ patients taking NRTI-containing HAART and compared it with similar cells from healthy individuals.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
