In the present study HIV-1 quasispecies were analysed in Langerhans cells derived from eight spli-thickness skin patches obtained from clinically normal skin taken soon after autopsy from an AIDS patients (coded RI). RI was an Italian drug user who had been HIV-1 Ab positive from 1986. It is not possible to formally conclude that patient RI was infected twice. RI could have been infected once by blood from a doubly infected individual. However double infection clearly must have occurred at some point. A number of independent experimental studies and phylogenetic analysis provides strong evidence for double infection. That detection is so infrequent might reflect the fact that a second infection most probably would occur in the face of HIV-specific immune response, so restricting viral replication.
|Data di pubblicazione:||1995|
|Titolo:||Discontinuous distribution of HIV-1 quasispecies in epidermal Langerhans cells of an AIDS patient and evidence for double infection.|
|Autori:||M. Sala; G. Zambruno; J.-P. Vartanian; A. Marconi; A. Giannetti; U. Bertazzoni; S. Wain-Hobson|
|Titolo del libro:||Dendritic Cells in Fundamental and Clinical Immunology|
|Nome editore:||Plenum Press|
|Appare nelle tipologie:||Capitolo/Saggio|
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