The effect of premedication with cromolyn 40 mg on the bronchial response to inhaled carbachol was investigated in four atopic and four non-atopic subjects with mild asthma. Paired carbachol inhalation tests were carried out on consecutive days in a double-blind fashion following randomized premedication with cromolyn or placebo. Bronchial sensitivity was expressed as the log dose of carbachol provoking a 15% decrease in FEV1 (log PD15 FEV1) or a 30% decrease in FEF25-75 (log PD30 FEF25-75). The mean log PD15 FEV1 was significantly greater following cromolyn compared to placebo (2.34 +/- .22 vs 1.87 +/- .10; mean +/- SE; p less than 0.05) as was log PD30 FEF25-75 (2.30 +/- .16 vs 1.72 +/- .08; p less than 0.005). These results indicate that cromolyn interferes with cholinergic induced bronchoconstriction and support the suggestion that it has an effect at a more fundamental level than the inhibition of antigen induced mediator release from mast cells.
Effect of cromolyn on carbachol-induced bronchoconstriction / Fabbri, Leonardo; C. E., Mapp; D. J., Hendrick. - In: ANNALS OF ALLERGY. - ISSN 0003-4738. - STAMPA. - 50(1983), pp. 195-198.
Data di pubblicazione: | 1983 |
Titolo: | Effect of cromolyn on carbachol-induced bronchoconstriction. |
Autore/i: | Fabbri, Leonardo; C. E., Mapp; D. J., Hendrick |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 50 |
Pagina iniziale: | 195 |
Pagina finale: | 198 |
Codice identificativo ISI: | WOS:A1983QJ14700010 |
Codice identificativo Scopus: | 2-s2.0-0020614393 |
Codice identificativo Pubmed: | 6402959 |
Citazione: | Effect of cromolyn on carbachol-induced bronchoconstriction / Fabbri, Leonardo; C. E., Mapp; D. J., Hendrick. - In: ANNALS OF ALLERGY. - ISSN 0003-4738. - STAMPA. - 50(1983), pp. 195-198. |
Tipologia | Articolo su rivista |
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