To determine whether inhaled beclomethasone, both at low and at high doses, inhibits late asthmatic reactions and the associated increase in airway responsiveness induced by toluene diisocyanate (TDI), we studied 9 sensitised subjects. Low dose beclomethasone (200 micrograms bid), high dose beclomethasone aerosol (1000 micrograms bid), and placebo were administered for 7 days before TDI inhalation challenge to each subject, according to a double-blind, crossover study design. The washout period between the treatments was at least 1 week. When the subjects were treated with placebo, forced expiratory volume in 1 sec (FEV1) markedly decreased after exposure to TDI. By contrast, high dose beclomethasone prevented the late asthmatic reaction and the low dose partially inhibited the reaction. With placebo the mean (+/- SE) value of FEV1 4 h after exposure to TDI was 2.6 +/- 0.17 L, which went to 3.3 +/- 0.12 after low dose beclomethasone, and to 3.5 +/- 0.15 L after high dose of beclomethasone (significant difference in the decrease of FEV1 in the 8 h after exposure to TDI, between treatments: F = 9.87, (P less than 0.001), After treatment with placebo or with low dose beclomethasone, airway responsiveness to methacholine increased 8 h after exposure to TDI. With placebo, the PD20 decreased from 0.66 mg (Geometric Standard Error of the Mean [GSEM], 1.38) to 0.18 mg (GSEM, 1.46); with low dose inhaled beclomethasone, the PD20 decreased from 0.93 mg (GSEM, 1.42) to 0.36 mg (GSEM, 1.63).
Dose-dependent inhibitory effect of inhaled beclomethasone on late asthmatic reactions and increased responsiveness to methacholine induced by toluene diisocyanate in sensitised subjects / N., De Marzo; Fabbri, Leonardo; S., Crescioli; M., Plebani; R., Testi; C. E., Mapp. - In: PULMONARY PHARMACOLOGY. - ISSN 0952-0600. - STAMPA. - 1(1988), pp. 15-20.
Data di pubblicazione: | 1988 |
Titolo: | Dose-dependent inhibitory effect of inhaled beclomethasone on late asthmatic reactions and increased responsiveness to methacholine induced by toluene diisocyanate in sensitised subjects. |
Autore/i: | N., De Marzo; Fabbri, Leonardo; S., Crescioli; M., Plebani; R., Testi; C. E., Mapp |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 1 |
Pagina iniziale: | 15 |
Pagina finale: | 20 |
Codice identificativo Scopus: | 2-s2.0-0024124608 |
Codice identificativo Pubmed: | 2856542 |
Citazione: | Dose-dependent inhibitory effect of inhaled beclomethasone on late asthmatic reactions and increased responsiveness to methacholine induced by toluene diisocyanate in sensitised subjects / N., De Marzo; Fabbri, Leonardo; S., Crescioli; M., Plebani; R., Testi; C. E., Mapp. - In: PULMONARY PHARMACOLOGY. - ISSN 0952-0600. - STAMPA. - 1(1988), pp. 15-20. |
Tipologia | Articolo su rivista |
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