162 subjects who had been exposed to isocyanates, who had developed symptoms during the exposure period, or in the evening or night and, therefore, had a history compatible with isocyanate-induced asthma, were studied with inhalation challenge testing to isocyanates (toluene diisocyanate and methylene diphenyl diisocyanate) and methacholine, because they were suspected of having occupational asthma. None of these subjects had symptomatic asthma before employment. The diagnosis of occupational asthma was delayed (duration of symptoms before diagnosis: 3.9 +/- 0.4 yrs). Isocyanate-asthma documented by a positive inhalation challenge to isocyanates was present in 57.4% of the subjects. A higher degree of airway responsiveness to methacholine was present in subjects with a positive isocyanate inhalation challenge compared to subjects with a negative challenge (Gmean and GESM: 0.407 (1.14) vs 0.942 (1.14) mg). The majority of the subjects complained of shortness of breath and cough. The low proportion of atopic subjects (21.5%) and of smokers (7.5%), and the high proportion of subjects with the late component in the asthmatic reaction (71%) appear to be common features in this disease.
Occupational asthma due to isocyanates / C. E., Mapp; P., Boschetto; L., Dal Vecchio; P., Maestrelli; Fabbri, Leonardo. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 1(1988), pp. 273-279.
|Data di pubblicazione:||1988|
|Titolo:||Occupational asthma due to isocyanates.|
|Autore/i:||C. E., Mapp; P., Boschetto; L., Dal Vecchio; P., Maestrelli; Fabbri, Leonardo|
|Codice identificativo ISI:||WOS:A1988P291400015|
|Codice identificativo Scopus:||2-s2.0-0023905051|
|Codice identificativo Pubmed:||3289963|
|Citazione:||Occupational asthma due to isocyanates / C. E., Mapp; P., Boschetto; L., Dal Vecchio; P., Maestrelli; Fabbri, Leonardo. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 1(1988), pp. 273-279.|
|Tipologia||Articolo su rivista|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris