CD4-positive T-lymphocytes infiltrate the bronchial mucosa of patients with Sjögren's syndrome.

Papiris, S. A.; Saetta, M.; Turato, G.; La Corte, R.; Trevisani, L.; Mapp, C. E.; Maestrelli, P.; Fabbri, Leonardo; Potena, A.

To investigate the degree and the type of inflammation in the bronchial mucosa in patients with Sjögren's syndrome, we examined lobar bronchial biopsies obtained from 10 patients with Sjögren's syndrome (six with primary and four with secondary) and eight control subjects. Histochemistry with hematoxylin-eosin was performed both to identify the number of mononuclear cells and eosinophils and to measure the thickness of the basement membrane. Immunohistochemistry was performed to identify neutrophils (neutrophil-elastase), macrophages (CD68), and T-lymphocyte subpopulations (CD4 and CD8) in the submucosa. Subjects with Sjögren's syndrome presented a greater number of CD4-positive T-lymphocytes than did the normal control subjects (p = 0.0129). Instead, eosinophils, neutrophils, macrophages, CD8 positive T-lymphocytes, and basement membrane thickness were similar in the two groups. There were no differences in cell counts between patients with primary and those with secondary Sjögren's syndrome and between symptomatic and asymptomatic patients. No correlation was found between cell counts, symptoms, lung volumes, and disease duration. This study has shown that patients with Sjögren's syndrome have an increased number of CD4 positive T-lymphocytes in the bronchial mucosa outside of the bronchial glands, supporting the concept that, in the airways, Sjögren's syndrome involves also extraglandular tissues.

CD4-positive T-lymphocytes infiltrate the bronchial mucosa of patients with Sjögren's syndrome / S. A., Papiris; M., Saetta; G., Turato; R., La Corte; L., Trevisani; C. E., Mapp; P., Maestrelli; Fabbri, Leonardo; A., Potena. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - STAMPA. - 156(1997), pp. 637-641.

Data di pubblicazione:	1997
Titolo:	CD4-positive T-lymphocytes infiltrate the bronchial mucosa of patients with Sjögren's syndrome.
Autore/i:	S. A., Papiris; M., Saetta; G., Turato; R., La Corte; L., Trevisani; C. E., Mapp; P., Maestrelli; Fabbri, Leonardo; A., Potena
Autore/i UNIMORE:	S. A. Papiris M. Saetta G. Turato R. La Corte L. Trevisani C. E. Mapp P. Maestrelli FABBRI, Leonardo A. Potena mostra contributor esterni nascondi contributor esterni
Rivista:	AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume:	156
Pagina iniziale:	637
Pagina finale:	641
Codice identificativo ISI:	WOS:A1997XR40800043
Codice identificativo Scopus:	2-s2.0-0030872519
Codice identificativo Pubmed:	9279251
Citazione:	CD4-positive T-lymphocytes infiltrate the bronchial mucosa of patients with Sjögren's syndrome / S. A., Papiris; M., Saetta; G., Turato; R., La Corte; L., Trevisani; C. E., Mapp; P., Maestrelli; Fabbri, Leonardo; A., Potena. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - STAMPA. - 156(1997), pp. 637-641.
Tipologia	Articolo su rivista

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