Reactive oxygen species (ROS) are important in the initiation and promotion of cells to neoplastic growth. Heme-oxygenase (HO)-1, the inducible form of heme-oxygenase, is a cytoprotective enzyme that plays a central role in the defence against oxidative stress and is implicated in the protection of lung tissue against exogenous oxidant exposure. We investigated whether the expression of HO-1 would be decreased in lung tumour as compared with tumour-free adjacent lung tissues. HO-1 expression was quantified by immunohistochemistry in tumour macrophages, in macrophages of tumour-free lung and in tumour cells of surgical specimens collected from 53 individuals with surgically resectable non-small cell lung cancer (NSCLC). The expression of HO-1 was decreased in tumour as compared with tumour-free lung macrophages. No correlations were observed between the expression of HO-1 and both the clinicopathological characteristics and the overall survival of the examined subjects. In conclusion, our data show that macrophages of non-small cell lung cancer exhibit impaired anti-oxidant defence mechanisms, likely mediated by HO-1. Conversely, HO-1 expression does not seem to be associated with lung tumour progression and prognosis.

Decreased heme-oxygenase (HO)-1 in the macrophages of non-small cell lung cancer / Piera, Boschetto; Elena, Zeni; Lucia, Mazzetti; Deborah, Miotto; Natalina Lo, Cascio; Piero, Maestrelli; Emanuela, Marian; Patrizia, Querzoli; Massimo, Pedriali; Bruno, Murer; Edoardo De, Rosa; Fabbri, Leonardo; Cristina E., Mapp. - In: LUNG CANCER. - ISSN 0169-5002. - STAMPA. - 59(2008), pp. 192-197.

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